Salmanroghani Hassan, Rouzegari Mohammad Hassan, Salmanroghani Roham
Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Gastroenterology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Caspian J Intern Med. 2022 Spring;13(2):398-404. doi: 10.22088/cjim.13.2.398.
Helicobacter pylori infection can be a risk factor for non-cardia gastric cancer. In the present study, we aimed to assess the rate of infection, its virulence factor and precancerous lesion among over 50 years old, dyspeptic patients with normal endoscopy.
A total of 620 patients over 50 years of age with dyspepsia that referred to Shahid Sadoughi Hospital, Yazd, Iran from December 2018 to January 2019 were evaluated. One hundred fifty patients with normal appearance endoscopy were selected, and six gastric biopsy specimens were taken from each subject. Data were analyzed using chi-square and logistic regression tests.
A total of 150 patients with mean age of 65.8±11.9 years old participated in this study. Sixty-three (42%) patients were males. Thirty-four (22.6%) patients had precancerous lesions. Ninety (60%) patients had positive PCR results for . infection test was positive in 24 (70.6%) patients with precancerous lesion. Sixty-six (57%) patients without the precancerous lesions (116 cases) were positive for
There was no a significant difference in the rate of infection and its genotype distribution was between patients with and without the precancerous lesions.
幽门螺杆菌感染可能是非贲门胃癌的一个危险因素。在本研究中，我们旨在评估50岁以上、内镜检查正常的消化不良患者中的感染率、其毒力因子和癌前病变情况。
对2018年12月至2019年1月转诊至伊朗亚兹德沙希德·萨杜基医院的620例50岁以上消化不良患者进行了评估。选择150例内镜外观正常的患者，从每个受试者身上采集6份胃活检标本。使用卡方检验和逻辑回归检验分析数据。
共有150例平均年龄为65.8±11.9岁的患者参与了本研究。其中63例（42%）为男性。34例（22.6%）患者有癌前病变。90例（60%）患者的PCR检测结果为阳性。24例（70.6%）有癌前病变的患者感染检测呈阳性。66例（57%）无癌前病变的患者（共116例）检测呈阳性。
有癌前病变和无癌前病变的患者在幽门螺杆菌感染率及其基因型分布上无显著差异。
