Department of Surgery, Saiseikai Fukuoka General Hospital, Japan.
Departments of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Am Surg. 2023 Nov;89(11):4452-4458. doi: 10.1177/00031348221117034. Epub 2022 Aug 3.
Increasing evidence indicates that increased systemic inflammation is correlated with poorer cancer-specific survival in various cancer types. This study aimed to evaluate the prognostic value of various combinations of inflammatory factors in patients who underwent surgical resection for pancreatic cancer (PC).
We retrospectively analyzed 97 consecutive patients with PC who underwent pancreatectomy. We assessed the predictive impact for recurrence using a combination of 5 inflammatory markers and focused on the lymphocyte-C-reactive protein ratio (LCR) to elucidate its prognostic and predictive value for recurrence-free survival (RFS) and overall survival (OS) in univariate and multivariate analyses using the Cox proportional hazards model.
Low preoperative LCR was correlated with low serum hemoglobin, low serum albumin concentration, high frequency of microscopic vascular invasion, and high frequency of microscopic perineural invasion. The low LCR group had significantly worse RFS and OS. Lower preoperative LCR was an independent predictor of shorter RFS and OS in this cohort.
Preoperative LCR is a novel and convenient prognostic marker for patients with PC. Patients with low LCR may require more favorable intensive therapy.
越来越多的证据表明，全身炎症反应增加与多种癌症类型的癌症特异性生存率降低相关。本研究旨在评估接受胰腺癌（PC）手术切除的患者中各种炎症因子组合的预后价值。
我们回顾性分析了 97 例接受胰腺切除术的 PC 连续患者。我们使用 5 种炎症标志物的组合评估了复发的预测影响，并重点关注淋巴细胞- C 反应蛋白比值（LCR），以使用 Cox 比例风险模型在单变量和多变量分析中阐明其对无复发生存（RFS）和总生存（OS）的预后和预测价值。
低术前 LCR 与低血清血红蛋白、低血清白蛋白浓度、微血管侵犯频率高和微神经周围侵犯频率高相关。低 LCR 组的 RFS 和 OS 明显更差。在本队列中，较低的术前 LCR 是 RFS 和 OS 较短的独立预测因素。
术前 LCR 是 PC 患者的一种新颖且方便的预后标志物。LCR 较低的患者可能需要更有利的强化治疗。
