Emergency Department, CHR Metz-Thionville, 57000 Metz, France.
Department of Public Health, University Hospital of Strasbourg, 67000 Strasbourg, France.
Int J Mol Sci. 2023 Mar 22;24(6):5996. doi: 10.3390/ijms24065996.
Health care systems worldwide have been battling the ongoing COVID-19 pandemic. Since the beginning of the COVID-19 pandemic, Lymphocytes and CRP have been reported as markers of interest. We chose to investigate the prognostic value of the LCR ratio as a marker of severity and mortality in COVID-19 infection. Between 1 March and 30 April 2020, we conducted a multicenter, retrospective cohort study of patients with moderate and severe coronavirus disease 19 (COVID-19), all of whom were hospitalized after being admitted to the Emergency Department (ED). We conducted our study in six major hospitals of northeast France, one of the outbreak's epicenters in Europe. A total of 1035 patients with COVID-19 were included in our study. Around three-quarters of them (76.2%) presented a moderate form of the disease, while the remaining quarter (23.8%) presented a severe form requiring admission to the ICU. At ED admission, the median LCR was significantly lower in the group presenting severe disease compared to that with moderate disease (versus 6.24 (3.24-12) versus 12.63 ((6.05-31.67)), < 0.001). However, LCR was neither associated with disease severity (OR: 0.99, CI 95% (0.99-1)), = 0.476) nor mortality (OR: 0.99, CI 95% (0.99-1)). In the ED, LCR, although modest, with a threshold of 12.63, was a predictive marker for severe forms of COVID-19.
全球的医疗体系一直在与持续的 COVID-19 大流行作斗争。自 COVID-19 大流行开始以来，淋巴细胞和 CRP 已被报告为有意义的标志物。我们选择研究 LCR 比值作为 COVID-19 感染严重程度和死亡率的标志物的预后价值。在 2020 年 3 月 1 日至 4 月 30 日期间，我们进行了一项多中心、回顾性队列研究，纳入了中度和重度冠状病毒病 19（COVID-19）患者，所有患者均在急诊科（ED）入院后住院。我们在法国东北部的六家主要医院进行了这项研究，这些医院是欧洲疫情的中心之一。共有 1035 名 COVID-19 患者纳入我们的研究。其中约四分之三（76.2%）患者表现为中度疾病，其余四分之一（23.8%）患者表现为需要入住 ICU 的严重疾病。在 ED 入院时，与中度疾病患者相比，严重疾病患者的 LCR 中位数明显更低（分别为 6.24（3.24-12）与 12.63（6.05-31.67），<0.001）。然而，LCR 既与疾病严重程度（OR：0.99，95%CI（0.99-1））无关，也与死亡率（OR：0.99，95%CI（0.99-1））无关。在 ED，LCR 虽然适度，但阈值为 12.63，是 COVID-19 严重形式的预测标志物。
