Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India.
Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India.
Cytokine. 2022 Oct;158:155980. doi: 10.1016/j.cyto.2022.155980. Epub 2022 Jul 31.
SARS-CoV-2 easily infects human monocytes, macrophages and possibly dendritic cells (DCs), causing dysfunctions of these important antigen presenting cells (APCs). Observed DC dysfunctions facilitate improper antigen presentation, which obviously results T cell anergy, exhaustion and apoptosis, thus, may be contributing significantly in SARS-CoV-2 infection associated lymphopenia. Neem Leaf Glycoprotein or NLGP has enormous role in altered DC functions, thereby, offering optimum T cell mediated cytotoxicity, as experienced from cancer system. Such NLGP guided correction of altered DCs might also be effective to generate proper SARS-CoV-2-specific effector and central memory T cells.
SARS-CoV-2 容易感染人类单核细胞、巨噬细胞和可能的树突状细胞 (DC)，导致这些重要抗原呈递细胞 (APC) 功能障碍。观察到的 DC 功能障碍促进了不当的抗原呈递，这显然导致 T 细胞失能、衰竭和凋亡，因此，可能在 SARS-CoV-2 感染相关的淋巴细胞减少症中起重要作用。印楝叶糖蛋白或 NLGP 在改变 DC 功能方面具有巨大作用，从而提供最佳的 T 细胞介导的细胞毒性，如在癌症系统中所经历的那样。这种 NLGP 指导的改变的 DC 的纠正也可能有效地产生适当的 SARS-CoV-2 特异性效应和中央记忆 T 细胞。
