Department Health Science, Oeste Paulista University - UNOESTE, Jaú, SP, Brazil.
Applied Physiology, Nutrition and Exercise Research Group - PhyNEr, Institute of Health Sciences, Federal University of Triangulo Mineiro - UFTM, Uberaba, Minas Gerais, Brazil.
Gynecol Endocrinol. 2022 Sep;38(9):765-770. doi: 10.1080/09513590.2022.2105832. Epub 2022 Aug 3.
To determine if higher levels of circulating interleukin (IL)-15 are positively associated with improvement in insulin resistance in postmenopausal women (PW) with metabolic syndrome (MS).
According to the median value of IL-15 at baseline, PW older than or equal to 45 years were divided into two groups: higher ( = 43) and lower ( = 42) IL-15. There was a 9-month follow-up period with clinical assessments at baseline and at 9 months (criteria of metabolic syndrome, body fat, and insulin resistance). Insulin resistance (IR) was calculated according to the Homeostasis Model Assessment-estimated insulin resistance (HOMA-IR). For IL-1β, IL-6, IL-10, IL-13, IL-33, IL-15, and TNF-α was determined using immunoassay Magnetic Bead Panel.
There was an interaction between the time and group only for insulin ( = .008) and HOMA-IR ( = .024). After adjusting for confounding variables (clinical and ILs), the HOMA-IR ( = .006) and insulin ( = .003) were lower in the higher-IL-15 group [HOMA-IR: 2.2 (95% CI: 1.9-2.5) and insulin: 9.1 µIU/mL (95% CI: 7.9-10.3)] when compared to the lower-IL-15 group [HOMA-IR: 3.1 (95% CI: 2.6-3.6) and insulin: 12.9 (95% CI: 11.1-14.9)] after 9 months of follow-up.
Higher levels of circulating IL-15 are positively associated with improvements in IR in PW with MS.
确定循环白细胞介素 (IL)-15 水平升高是否与改善患有代谢综合征 (MS) 的绝经后妇女 (PW) 的胰岛素抵抗有关。
根据基线时 IL-15 的中位数值，将年龄大于或等于 45 岁的 PW 分为两组：较高（=43）和较低（=42）IL-15。有 9 个月的随访期，在基线和 9 个月时进行临床评估（代谢综合征标准、体脂肪和胰岛素抵抗）。根据稳态模型评估-估计胰岛素抵抗（HOMA-IR）计算胰岛素抵抗（IR）。使用免疫测定磁珠面板测定 IL-1β、IL-6、IL-10、IL-13、IL-33、IL-15 和 TNF-α。
仅在胰岛素（=0.008）和 HOMA-IR（=0.024）方面，时间与组之间存在交互作用。在调整混杂变量（临床和 ILs）后，高 IL-15 组的 HOMA-IR（=0.006）和胰岛素（=0.003）较低[HOMA-IR：2.2（95%CI：1.9-2.5）和胰岛素：9.1µIU/mL（95%CI：7.9-10.3）]，而低 IL-15 组[HOMA-IR：3.1（95%CI：2.6-3.6）和胰岛素：12.9（95%CI：11.1-14.9）]在 9 个月的随访后。
循环 IL-15 水平升高与 MS 绝经后妇女的 IR 改善呈正相关。
