Department of Health Sciences, Universidade do Oeste Paulista - UNOESTE, Jaú, Brazil.
Applied Physiology, Nutrition and Exercise Research Group- PhyNEr, Institute of Health Sciences, Federal University of Triangulo Mineiro - UFTM, Uberaba, Brazil.
Women Health. 2024 Aug;64(7):584-594. doi: 10.1080/03630242.2024.2383289. Epub 2024 Jul 31.
This study aims to investigate the potential association between serum levels of cytokines, HSP60, HSP70 and IR (HOMA-IR) in postmenopausal women. We conducted a cross-sectional study involving 381 postmenopausal women, including 94 with a breast cancer diagnosis and 278 without. We analyzed anthropometric and laboratory measurements. Immunoassays were used to measure cytokines (TNF-α, IL-10, and IL-6) as well as heat shock proteins (HSP) 60 and 70 in the serum using the ELISA technique. Women diagnosed with breast cancer showed higher levels of HOMA-IR, IL-6, TNF, and HSP60, and lower levels of IL-10 and HSP70 compared to women without cancer. An association was found between HSP70 and HOMA-IR only in women with breast cancer (β = 0.22, = .030; without cancer: β = 0.04, = .404), regardless of age, waist circumference, smoking, and physical activity. No associations were observed between cytokines, HSP60, and HOMA-IR in both groups of women. HSP70 is positively associated with IR in women diagnosed with breast cancer.
本研究旨在探讨绝经后妇女血清细胞因子、热休克蛋白 60（HSP60）、热休克蛋白 70（HSP70）和胰岛素抵抗（HOMA-IR）之间的潜在关联。我们进行了一项横断面研究，纳入了 381 名绝经后妇女，其中 94 名患有乳腺癌，278 名无乳腺癌。我们分析了人体测量学和实验室测量值。采用 ELISA 技术，通过免疫测定法检测血清中的细胞因子（TNF-α、IL-10 和 IL-6）以及热休克蛋白（HSP）60 和 70。与无癌症的女性相比，患有乳腺癌的女性的 HOMA-IR、IL-6、TNF 和 HSP60 水平更高，而 IL-10 和 HSP70 水平更低。仅在患有乳腺癌的女性中发现 HSP70 与 HOMA-IR 之间存在关联（β=0.22，P=0.030；无癌症：β=0.04，P=0.404），与年龄、腰围、吸烟和体力活动无关。在两组女性中均未观察到细胞因子、HSP60 与 HOMA-IR 之间存在关联。在诊断为乳腺癌的女性中，HSP70 与 IR 呈正相关。
