Zhonghua Nei Ke Za Zhi. 2022 Aug 1;61(8):860-866. doi: 10.3760/cma.j.cn112138-20220615-00452.
Transarterial chemoembolization (TACE) is the fundamental method for the treatment of unresectable hepatocellular carcinoma (HCC). Nevertheless, ineffective repeat TACE may lead to damage on liver function and therefore have negative effect on long-term prognosis of HCC. The concept of "TACE failure/refractoriness" was then proposed to avoid ineffective repeat TACE. Nevertheless, whether the existing definitions of "TACE failure/refractoriness" are applicable to Chinese HCCs remains to be discussed. Combining reported clinical evidence with experts' opinion, the Chinese College of Interventionalists (CCI) TACE Refractoriness Collaboration Group proposed the CCI definition and expert consensus on TACE refractoriness in 2021. The CCI definition and expert consensus aims to make the concept of TACE refractoriness more scientific and objective, so as to better guide clinical practice of TACE for patients with HCC in China.
经动脉化疗栓塞术（TACE）是治疗不可切除肝细胞癌（HCC）的基本方法。然而，无效的重复TACE可能导致肝功能损害，从而对HCC的长期预后产生负面影响。因此，提出了“TACE失败/难治性”的概念，以避免无效的重复TACE。然而，现有的“TACE失败/难治性”定义是否适用于中国HCC患者仍有待讨论。结合已报道的临床证据和专家意见，中国介入医师学会（CCI）TACE难治性协作组于2021年提出了CCI关于TACE难治性的定义和专家共识。CCI定义和专家共识旨在使TACE难治性的概念更加科学和客观，以便更好地指导中国HCC患者TACE的临床实践。
