Yang Y Y, Tang S W, Tang W, Fan J L, Li Z, Yang J W, Ren J, Li C S
Department of Pathogen Biological Detection, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Department of Infectious Disease Prevention and Control, Shanghai Minhang District Municipal Center for Disease Control and Prevention, Shanghai 201101, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Aug 6;56(8):1095-1100. doi: 10.3760/cma.j.cn112150-20211116-01057.
To determine IgG antibody levels of measles, rubella, mumps in healthy population in Shanghai from 2010 to 2020 and analyze the trend of antibody changes in different age groups. 10 828 healthy people without measles, rubella and mumps in Shanghai were included in the study from 2010 to 2020. Serum samples were collected from 12 age groups, and the serum IgG antibody of measles, rubella and mumps were detected by ELISA. The difference of antibody positive rates and antibody levels were analyzed. The median age (, ) of 10 828 objects were 8 years old (9 months old, 20 years old). Males accounted for 48.34% (5 234/10 828) and females accounted for 50.92% (5 514/10 828). Unknown gender information accounted for 0.74% (80/10 828), and 27.03% (2 927/10 828) of participants had unknown MMR immunization history. The total positive rates of measles, rubella and mumps IgG antibody were 76.78%, 64.46% and 64.29% and their GMCs were 541.45 mIU/ml, 31.76 IU/ml and 133.73 U/ml respectively. There were significant differences in serum IgG antibody GMC of measles, rubella and mumps in each year (=180.74, <0.001; =189.95, <0.001; =122.40, <0.001). The positive rate of measles antibody was higher than that of rubella and mumps, and the difference was statistically significant (χ²=518.09, <0.001). The level of measles IgG antibody in healthy people in Shanghai is higher, while the level of rubella and mumps IgG antibody is slightly lower.
了解2010年至2020年上海市健康人群麻疹、风疹、流行性腮腺炎IgG抗体水平，分析不同年龄组抗体变化趋势。2010年至2020年纳入上海市10828名无麻疹、风疹、流行性腮腺炎病史的健康人进行研究。采集12个年龄组的血清样本，采用ELISA法检测麻疹、风疹、流行性腮腺炎血清IgG抗体。分析抗体阳性率及抗体水平差异。10828名研究对象的年龄中位数（，）为8岁（9个月，20岁）。男性占48.34%（5234/10828），女性占50.92%（5514/10828）。性别信息不详者占0.74%（80/10828），27.03%（2927/10828）的参与者麻疹、腮腺炎、风疹疫苗接种史不详。麻疹、风疹、流行性腮腺炎IgG抗体总阳性率分别为76.78%、64.46%和64.29%，几何平均浓度（GMC）分别为541.45 mIU/ml、31.76 IU/ml和133.73 U/ml。每年麻疹、风疹、流行性腮腺炎血清IgG抗体GMC差异均有统计学意义（=180.74，<0.001；=189.95，<0.001；=122.40，<0.001）。麻疹抗体阳性率高于风疹和流行性腮腺炎，差异有统计学意义（χ²=518.09，<0.001）。上海市健康人群麻疹IgG抗体水平较高，风疹和流行性腮腺炎IgG抗体水平稍低。
