School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Front Immunol. 2024 Nov 12;15:1472189. doi: 10.3389/fimmu.2024.1472189. eCollection 2024.
To gain a comprehensive understanding of rubella seroprevalence in the healthy population in China and to offer data-driven support for the goal of rubella elimination.
CNKI, Wanfang database, VIP database, CBM, PubMed, web of Science, and Embase databases were searched to collect studies reporting the positive rate of rubella antibody among the Chinese healthy populations between 2001 and 2022. We conducted a meta-analysis using R language, and data were combined using random effects model.
A total of 97 studies were included, encompassing a sample size of 103,018. Meta-analysis showed that the overall prevalence of rubella antibody positivity in the Chinese healthy population was 77.29% (95% CI: 75.26-79.33). The prevalence of rubella antibody varied significantly based on age and vaccination status. Among the age groups studied, the <1-year-old group exhibited the lowest positivity rate for rubella antibody at 47.87% (95% CI: 41.53-54.21),while the ≥50 years old group showed the highest positivity rate at 85.43% (95% CI: 81.01-89.85); individuals with a history of vaccination demonstrated a higher antibody positivity rate compared to those without vaccination history.
The prevalence of rubella antibody in healthy Chinese population is relatively low. In order to establish a solid immunity threshold levels, it requires conducting timely immunization programs on key groups such as middle school students and the women of childbearing age on the basis of ensuring a high level of rubella-containing-vaccines (RCV) coverage, so as to achieve the goal of eliminating rubella.
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024607949.
全面了解中国健康人群风疹血清流行率，为消除风疹目标提供数据支持。
检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Web of Science 和 Embase 数据库，收集 2001 年至 2022 年中国健康人群风疹抗体阳性率的研究。使用 R 语言进行荟萃分析，采用随机效应模型进行数据合并。
共纳入 97 项研究，样本量为 103018 例。荟萃分析显示，中国健康人群风疹抗体总阳性率为 77.29%（95%CI：75.26%79.33%）。风疹抗体阳性率随年龄和疫苗接种状态而异。在所研究的年龄组中，<1 岁组风疹抗体阳性率最低，为 47.87%（95%CI：41.53%54.21%），≥50 岁组最高，为 85.43%（95%CI：81.01%~89.85%）；有疫苗接种史者抗体阳性率高于无疫苗接种史者。
中国健康人群风疹抗体阳性率较低。为建立稳定的免疫阈值水平，在确保风疹疫苗（RCV）高覆盖率的基础上，需要对中学生和育龄妇女等重点人群及时开展免疫规划，以实现消除风疹的目标。
https://www.crd.york.ac.uk/PROSPERO/，标识符 CRD42024607949。
