氟烷比异氟烷更能舒张先前已收缩的离体猪冠状动脉节段。

Halothane relaxes previously constricted isolated porcine coronary artery segments more than isoflurane.

作者信息

Bollen B A, Tinker J H, Hermsmeyer K

出版信息

Anesthesiology. 1987 Jun;66(6):748-52. doi: 10.1097/00000542-198706000-00007.

DOI:10.1097/00000542-198706000-00007

Abstract

Coronary vasodilation by halothane and isoflurane were compared using in vitro tension recording. Porcine left anterior descending coronary arterial segments (1.5-2.0 mm o.d.) were constricted with either K+ (30 mM) or prostanoid U44069 (6 X 10(-7) M) in the absence of other drugs or anesthetics. Following stabilization of constriction, arteries were exposed to halothane or isoflurane at 0.5, 1.0, 1.5, 2.0, and 3.0% concentrations. K+ (30 mM) induced constriction was reduced by halothane at 1.5, 2.0, and 3.0% and U44069 (6 X 10(-7) M) induced constriction was reduced at 0.5, 1.0, 1.5, 2.0, and 3.0%. K+ (30 mM) induced constriction was reduced by isoflurane only at 3.0% and U44069 (6 X 10(-7) M) induced constriction was reduced by isoflurane only at 2.0 and 3.0%. U44069 induced constriction was more susceptible than K+ induced constriction to relaxation by halothane or isoflurane. Halothane was more potent than isoflurane as a direct relaxant of porcine epicardial left anterior descending arterial segments previously constricted with K+ (30 mM) or U44069 (6 X 10(-7) M).

摘要

采用体外张力记录法比较了氟烷和异氟烷对冠状动脉的舒张作用。在无其他药物或麻醉剂的情况下，用钾离子（30 mM）或前列腺素U44069（6×10⁻⁷ M）使猪左前降支冠状动脉节段（外径1.5 - 2.0 mm）收缩。收缩稳定后，将动脉分别暴露于浓度为0.5%、1.0%、1.5%、2.0%和3.0%的氟烷或异氟烷中。1.5%、2.0%和3.0%的氟烷可减轻钾离子（30 mM）诱导的收缩，0.5%、1.0%、1.5%、2.0%和3.0%的氟烷可减轻U44069（6×10⁻⁷ M）诱导的收缩。只有3.0%的异氟烷可减轻钾离子（30 mM）诱导的收缩，只有2.0%和3.0%的异氟烷可减轻U44069（6×10⁻⁷ M）诱导的收缩。U44069诱导的收缩比钾离子诱导的收缩对氟烷或异氟烷的舒张作用更敏感。作为猪心外膜左前降支动脉节段（先前已用钾离子（30 mM）或U44069（6×10⁻⁷ M）收缩）的直接舒张剂，氟烷比异氟烷更有效。