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在雷恩研究中,10 岁时发育性语言障碍的流行情况和潜在危险因素。

The prevalence of and potential risk factors for Developmental Language Disorder at 10 years in the Raine Study.

机构信息

School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.

Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia.

出版信息

J Paediatr Child Health. 2022 Nov;58(11):2044-2050. doi: 10.1111/jpc.16149. Epub 2022 Aug 3.

Abstract

AIM

This study sought to determine the prevalence of Developmental Language Disorder (DLD) in Australian school-aged children and associated potential risk factors for DLD at 10 years.

METHODS

This study used a cross-sectional design to estimate the prevalence of DLD in Generation 2 of the prospective Raine Study. Participants included 1626 children aged 10 years with available language data. Primary outcomes included variables matching diagnostic criteria for DLD. Associations of other potential prenatal and environmental variables were analysed as secondary outcomes.

RESULTS

The prevalence of DLD in this sample was 6.4% (n = 104) at 10 years. This sub-cohort comprised 33.7% (n = 35) with expressive language deficits, 20.2% (n = 21) with receptive language deficits, and 46.2% (n = 48) with receptive-expressive deficits. No significant difference in sex distribution was observed (52.9% male, p = 0.799). Children who were exposed to smoke in utero at 18 weeks gestation were at increased risk of DLD at 10 years (OR = 2.56, CI = 1.23-5.35, p = 0.012).

CONCLUSIONS

DLD is a relatively prevalent condition in Australian children, even when assessed in middle childhood years. These findings can inform future research priorities, and public health and educational policy which account for the associations with potential risk factors.

摘要

目的

本研究旨在确定澳大利亚学龄儿童发育性语言障碍(DLD)的患病率,并确定 10 岁时 DLD 的潜在相关风险因素。

方法

本研究采用横断面设计,估计前瞻性 Raine 研究第二代中 DLD 的患病率。参与者包括 1626 名 10 岁且有语言数据的儿童。主要结局包括符合 DLD 诊断标准的变量。将其他潜在的产前和环境变量的关联作为次要结局进行分析。

结果

在该样本中,10 岁时 DLD 的患病率为 6.4%(n=104)。该亚组包括 33.7%(n=35)有表达性语言缺陷,20.2%(n=21)有接受性语言缺陷,46.2%(n=48)有接受-表达性缺陷。性别分布无显著差异(52.9%为男性,p=0.799)。在 18 周妊娠时暴露于宫内烟雾的儿童在 10 岁时患 DLD 的风险增加(OR=2.56,CI=1.23-5.35,p=0.012)。

结论

即使在儿童中期评估,DLD 在澳大利亚儿童中也是一种较为普遍的疾病。这些发现可以为未来的研究重点以及考虑潜在风险因素的公共卫生和教育政策提供信息。

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