评估 ω-3 脂肪酸及其代谢物对癌细胞生长的抑制作用。

Evaluation of Cancer Cell Growth Suppressibility of ω-3 Fatty Acids and Their Metabolites.

机构信息

Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science.

Research Institute for Science and Technology, Tokyo University of Science.

出版信息

J Oleo Sci. 2022;71(8):1253-1260. doi: 10.5650/jos.ess22183.

DOI:10.5650/jos.ess22183

PMID:35922933

Abstract

According to current research, cancer cell growth is suppressed by ω-3 fatty acids, which are essential fatty acids. On the other hand, ω-3 fatty acids are metabolized to bioactivities in vivo. A systematic evaluation of the ability of ω-3 fatty acids and their metabolites to suppress cancer cell growth has not been sufficiently conducted. Our work evaluated the effect of ω-3 fatty acids (docosahexaenoic acid, eicosapentaenoic acid), trans fatty acid, and the metabolites (Resolvin E1, Maresin 1) on cancer cell growth suppressibility. Our results suggest that there may be optimal fatty acids depending on the kind of cancer cells, the presence or absence of hydroxyl group, and the double bond structure involved.

摘要

根据目前的研究，ω-3 脂肪酸是必需脂肪酸，能抑制癌细胞生长。另一方面，ω-3 脂肪酸在体内代谢为具有生物活性的物质。尚未充分进行系统评估 ω-3 脂肪酸及其代谢物抑制癌细胞生长的能力。我们的工作评估了 ω-3 脂肪酸（二十二碳六烯酸、二十碳五烯酸）、反式脂肪酸和代谢物（Resolvin E1、Maresin 1）对癌细胞生长抑制能力的影响。我们的研究结果表明，可能存在最佳的脂肪酸，具体取决于癌细胞的种类、羟基的存在与否以及涉及的双键结构。