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未进行治疗性引流的耳源性脑脓肿的药物治疗结果:一例中枢性眩晕病例

Outcome of medical treatment of otogenic brain abcess without therapeutic drainage: A case of central vertigo.

作者信息

Pribadi Soni Azhar, Prasetio Aan Dwi, Irsalina Putri, Islamiyah Wardah Rahmatul, Sugianto Paulus

机构信息

Department of Neurology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.

出版信息

Radiol Case Rep. 2022 Jul 28;17(10):3559-3563. doi: 10.1016/j.radcr.2022.06.102. eCollection 2022 Oct.

Abstract

Otogenic brain abscess is a severe infection that must be treated as early as possible. Rare cases with a high mortality rate can be reduced by recognizing the red flags of a brain abscess, such as headaches, mental status changes, fever, and focal neurological deficits. Those could be supported by modern diagnostic management and adequate antibiotic therapy that was able to penetrate the central nervous system and abscesses. We report a case of a cerebellar abscess of the 49-year-old man with the chief complaint of vertigo. It was accompanied by chronic progressive headache, fever, bidirectional nystagmus, abnormal Romberg test, and abnormal cerebellar signs. Magnetic resonance imaging (MRI) of the head with contrast showed a right cerebellar abscess with an infectious source of otitis media and mastoiditis. The MRI evaluation showed improvement after admistered metronidazole 500 mg every 6 hours (week 22) and cefixime 200 mg every 12 hours (week 13). Long-term antibiotic treatment can be an alternative if surgery cannot be performed. However, surgery is still considered if there is no good clinical response during medical therapy.

摘要

耳源性脑脓肿是一种严重的感染,必须尽早治疗。通过识别脑脓肿的警示信号,如头痛、精神状态改变、发热和局灶性神经功能缺损,可以减少罕见的高死亡率病例。这些可以通过现代诊断管理和能够穿透中枢神经系统及脓肿的适当抗生素治疗来支持。我们报告一例49岁男性小脑脓肿病例,主要症状为眩晕。伴有慢性进行性头痛、发热、双向眼球震颤、闭目难立试验异常和小脑体征异常。头颅磁共振成像(MRI)增强扫描显示右侧小脑脓肿,感染源为中耳炎和乳突炎。在每6小时给予500毫克甲硝唑(第22周)和每12小时给予200毫克头孢克肟(第13周)后,MRI评估显示病情有所改善。如果无法进行手术,长期抗生素治疗可以作为一种替代方案。然而,如果在药物治疗期间没有良好的临床反应,仍考虑进行手术治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb5/9340120/6fb22c826986/gr1.jpg

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