Lukianov D A, Buev V S, Ivanenkov Y A, Kartsev V G, Skvortsov D A, Osterman I A, Sergiev P V
Skolkovo Institute of Science and Technology, Center of Life Sciences, Skolkovo, 143028 Russia.
Lomonosov Moscow State University, Chemistry Department, Moscow, 119991 Russia.
Acta Naturae. 2022 Apr-Jun;14(2):71-77. doi: 10.32607/actanaturae.11654.
Searching for novel compounds with antibiotic activity and understanding their mechanism of action is extremely important. The ribosome is one of the main targets for antibiotics in bacterial cells. Even if the molecule does not suit the clinical application for whatever reasons, an investigation of its mechanism of action can deepen our understanding of the ribosome function. Such data can inform us on how the already used translational inhibitors can be modified. In this study, we demonstrate that 1-(2-oxo-2-((4-phenoxyphenyl).
寻找具有抗生素活性的新型化合物并了解其作用机制极其重要。核糖体是细菌细胞中抗生素的主要靶点之一。即使该分子由于任何原因不适合临床应用，对其作用机制的研究也可以加深我们对核糖体功能的理解。这些数据可以告诉我们如何对已使用的翻译抑制剂进行修饰。在本研究中，我们证明了1-(2-氧代-2-((4-苯氧基苯基)。 （注：原文最后似乎不完整）
