Vestweber J G, Al-Ani F K, Johnson D E
Am J Vet Res. 1987 Apr;48(4):673-5.
Before injection of diuretic drugs, blood pressures were determined in the cranial superficial epigastric veins (milk vein) and jugular veins of 15 Holstein cows with udder edema at parturition and of 15 healthy (control) cows at parturition. Cows with udder edema had a significant (P less than or equal to 0.05) mean increase in cranial superficial epigastric venous pressure at parturition, compared with that of control cows. After IV administration of 500 mg of furosemide in cows with udder edema, the mean cranial superficial epigastric venous blood pressure significantly (P less than or equal to 0.05) decreased within 5 minutes, remained at the decreased pressure for 90 minutes, and then returned to near pretreatment pressures by 210 minutes after furosemide injection; however, furosemide did not significantly affect the jugular venous blood pressure of these cows. Furosemide injection did not significantly affect the cranial superficial epigastric or jugular venous blood pressure in the control cows. After IV administration of hydrochlorothiazide (250 mg), acetazolamide (500 mg), or 50% dextrose (500 g), the cranial superficial epigastric and jugular venous blood pressures in cows with udder edema at parturition were not significantly different from those in cows without udder edema at parturition during the 210-minute evaluation period after injection of the drugs.
在注射利尿药物之前，测定了15头分娩时患有乳房水肿的荷斯坦奶牛以及15头健康（对照）奶牛分娩时颅浅表腹壁静脉（乳静脉）和颈静脉的血压。与对照奶牛相比，患有乳房水肿的奶牛在分娩时颅浅表腹壁静脉压平均显著升高（P≤0.05）。给患有乳房水肿的奶牛静脉注射500 mg速尿后，颅浅表腹壁静脉平均血压在5分钟内显著降低（P≤0.05），在降低的压力水平维持90分钟，然后在注射速尿后210分钟时恢复到接近预处理时的压力；然而，速尿对这些奶牛的颈静脉血压没有显著影响。注射速尿对对照奶牛的颅浅表腹壁静脉或颈静脉血压没有显著影响。静脉注射氢氯噻嗪（250 mg）、乙酰唑胺（500 mg）或50%葡萄糖（500 g）后，在注射药物后的210分钟评估期内，分娩时患有乳房水肿的奶牛的颅浅表腹壁静脉和颈静脉血压与分娩时未患乳房水肿的奶牛相比无显著差异。
