Hemming Joanna M, Szyroka Justyna, Shokano Gracia, Arnold Thomas, Skoda Maximilian W A, Rennie Adrian R, Thompson Katherine C
Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London Malet Street London WC1E 7HX UK
European Spallation Source The ESS Campus Lund Sweden SE-221 00.
Environ Sci Atmos. 2022 Jun 14;2(4):753-760. doi: 10.1039/d2ea00032f. eCollection 2022 Jul 14.
Exposure to the secondary pollutant ozone in ambient air is associated with adverse health effects when inhaled. In this work we use surface pressure measurements, combined with X-ray and neutron reflection, to observe changes in a layer of lung surfactant at the air water interface when exposed to gas phase ozone. The results demonstrate that the layer reacts with ozone changing its physical characteristics. A slight loss of material, a significant thinning of the layer and increased hydration of the surfactant material is observed. The results support the hypothesis that unsaturated lipids present in lung surfactant are still susceptible to rapid reaction with ozone and the reaction changes the properties of the interfacial layer.
吸入环境空气中的二次污染物臭氧会对健康产生不利影响。在这项工作中，我们结合表面压力测量以及X射线和中子反射技术，观察气相臭氧作用下空气-水界面处肺表面活性剂层的变化。结果表明，该层与臭氧发生反应，改变了其物理特性。观察到有轻微的物质损失、该层显著变薄以及表面活性剂材料的水合作用增加。这些结果支持了以下假设：肺表面活性剂中存在的不饱和脂质仍然易于与臭氧快速反应，并且这种反应会改变界面层的性质。
