Rana Deepshikha, Hazarika Himadri, Agarwal Aditi, Gupta Richa, Kotru Mrinalini
Pathology, University College of Medical Sciences, New Delhi, IND.
Pathology, Dr. Ram Manohar Lohia Hospital, Delhi, IND.
Cureus. 2022 Jun 30;14(6):e26446. doi: 10.7759/cureus.26446. eCollection 2022 Jun.
Background Neonatal sepsis is considered a ubiquitous worldwide cause of mortality and morbidity in newborn infants. The incidence is 10-50 per 1000 live births. Neutrophil to lymphocyte ratio (NLR) is an easily accessible and cost-effective hematological marker for prompt diagnosis of neonatal sepsis. Aim and objectives The purpose of this study was to analyze the clinical significance of NLR in neonates clinically diagnosed with sepsis and its impact on the management. Methods This retrospective study was conducted on 265 neonates diagnosed with sepsis and compared with 341 healthy controls. The statistical analysis was performed by using the Student's t-test to compare the variables. Result Median NLR levels were significantly higher in patients than in controls. NLR had a modest power of predicting neonatal sepsis, as suggested by an area under a curve of 0.569. Conclusion NLR is an important predictor of neonatal sepsis. There is a significant modest positive correlation between NLR and sepsis.
新生儿败血症被认为是全球范围内新生儿死亡和发病的普遍原因。发病率为每1000例活产中有10 - 50例。中性粒细胞与淋巴细胞比值（NLR）是一种易于获取且成本效益高的血液学标志物，可用于快速诊断新生儿败血症。
本研究的目的是分析NLR在临床诊断为败血症的新生儿中的临床意义及其对治疗的影响。
本回顾性研究对265例诊断为败血症的新生儿进行，并与341例健康对照进行比较。采用学生t检验进行统计分析以比较变量。
患者的NLR中位数水平显著高于对照组。NLR预测新生儿败血症的能力中等，曲线下面积为0.569表明了这一点。
NLR是新生儿败血症的重要预测指标。NLR与败血症之间存在显著的中等程度正相关。
