Brown M P, Gronwall R, Gossman T B, Houston A E
Am J Vet Res. 1987 May;48(5):805-6.
Six healthy foals, from 4 to 6 days of age, were given a single IM injection of sodium cephapirin (250 mg/ml) at a rate of 20 mg/kg of body weight. Serum concentrations of cephapirin were measured serially over an 8-hour period. The mean peak serum concentration was 21.2 micrograms/ml at 10 minutes. The overall elimination rate constant was 1.06/hr and the elimination half-life was 0.70 hour. The apparent volume of distribution at steady state was 1.06 L/kg and plasma clearance was 1,105 ml/hr/kg.
六匹4至6日龄的健康马驹，以20毫克/千克体重的剂量单次肌肉注射头孢匹林钠（250毫克/毫升）。在8小时内连续测定血清中头孢匹林的浓度。10分钟时的平均血清峰值浓度为21.2微克/毫升。总体消除速率常数为1.06/小时，消除半衰期为0.70小时。稳态时的表观分布容积为1.06升/千克，血浆清除率为1105毫升/小时/千克。
