Chekol Abebe Endeshaw, Tilahun Muche Zelalem, Behaile T/Mariam Awigchew, Mengie Ayele Teklie, Mekonnen Agidew Melaku, Teshome Azezew Muluken, Abebe Zewde Edgeit, Asmamaw Dejenie Tadesse, Asmamaw Mengstie Misganaw
Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Front Cell Dev Biol. 2022 Jul 18;10:945287. doi: 10.3389/fcell.2022.945287. eCollection 2022.
Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is predominantly expressed in embryonic cells and adult hepatocytes, and to a lesser extent in adipocytes and monocytes. Fetuin-A binds with a plethora of receptors and exhibits multifaceted physiological and pathological functions. It is involved in the regulation of calcium metabolism, osteogenesis, and the insulin signaling pathway. It also acts as an ectopic calcification inhibitor, protease inhibitor, inflammatory mediator, anti-inflammatory partner, atherogenic factor, and adipogenic factor, among other several moonlighting functions. Fetuin-A has also been demonstrated to play a crucial role in the pathogenesis of several disorders. This review mainly focuses on the structure, synthesis, and biological roles of fetuin-A. Information was gathered manually from various journals electronic searches using PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. Studies written in English and cohort, case-control, cross-sectional, or experimental studies were considered in the review, otherwise excluded.
胎球蛋白-A是一种异源二聚体血浆糖蛋白，由一条含282个氨基酸的A链和一条含27个氨基酸残基的B链通过一个二硫键连接而成。它主要在胚胎细胞和成年肝细胞中表达，在脂肪细胞和单核细胞中的表达程度较低。胎球蛋白-A与众多受体结合，并表现出多方面的生理和病理功能。它参与钙代谢、骨生成和胰岛素信号通路的调节。它还可作为异位钙化抑制剂、蛋白酶抑制剂、炎症介质、抗炎伴侣、致动脉粥样硬化因子和脂肪生成因子等多种兼职功能。胎球蛋白-A也已被证明在多种疾病的发病机制中起关键作用。本综述主要关注胎球蛋白-A的结构、合成及其生物学作用。信息通过从创刊到2022年使用PubMed、谷歌学术、HINARI和考科蓝图书馆进行的各种期刊电子检索手动收集。综述纳入了用英文撰写的队列研究、病例对照研究、横断面研究或实验研究，否则予以排除。
