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Potential roles of gut microbiota and microbial metabolites in chronic inflammatory pain and the mechanisms of therapy drugs.

作者信息

Li Jia-Shang, Su Shu-Lan, Xu Zhuo, Zhao Li-Hui, Fan Ruo-Ying, Guo Jian-Ming, Qian Da-Wei, Duan Jin-Ao

机构信息

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, P.R. China.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, P.R. China.

出版信息

Ther Adv Chronic Dis. 2022 Jul 28;13:20406223221091177. doi: 10.1177/20406223221091177. eCollection 2022.

DOI:10.1177/20406223221091177
PMID:35924009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9340317/
Abstract

Observational findings achieved that gut microbes mediate human metabolic health and disease risk. The types of intestinal microorganisms depend on the intake of food and drugs and are also related to their metabolic level and genetic factors. Recent studies have shown that chronic inflammatory pain is closely related to intestinal microbial homeostasis. Compared with the normal intestinal flora, the composition of intestinal flora in patients with chronic inflammatory pain had significant changes in , , , etc. At the same time, short-chain fatty acids and amino acids, the metabolites of intestinal microorganisms, can regulate neural signal molecules and signaling pathways, thus affecting the development trend of chronic inflammatory pain. Glucocorticoids and non-steroidal anti-inflammatory drugs in the treatment of chronic inflammatory pain, the main mechanism is to affect the secretion of inflammatory factors and the abundance of intestinal bacteria. This article reviews the relationship between intestinal microorganisms and their metabolites on chronic inflammatory pain and the possible mechanism.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1a/9340317/a50850da2f6f/10.1177_20406223221091177-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1a/9340317/3fd7dcb59777/10.1177_20406223221091177-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1a/9340317/b4ef0d676297/10.1177_20406223221091177-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1a/9340317/a50850da2f6f/10.1177_20406223221091177-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1a/9340317/3fd7dcb59777/10.1177_20406223221091177-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1a/9340317/b4ef0d676297/10.1177_20406223221091177-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1a/9340317/a50850da2f6f/10.1177_20406223221091177-fig3.jpg

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Potential roles of gut microbiota and microbial metabolites in chronic inflammatory pain and the mechanisms of therapy drugs.

Ther Adv Chronic Dis. 2022-7-28

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Causal Effects of Artificially Sweetened Foods on Chronic Pain Mediated by Gut Microbiota: A Mendelian Randomization Study.

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[2]
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[3]
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[4]
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[5]
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[6]
Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study.

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[7]
Pogostemon cablin (Blanco) Benth granule revealed a positive effect on improving intestinal barrier function and fecal microbiota in mice with irinotecan-induced intestinal mucositis.

Arch Microbiol. 2023-4-8

[8]
Exploring the alterations and function of skin microbiome mediated by ionizing radiation injury.

Front Cell Infect Microbiol. 2022

本文引用的文献

[1]
Variation of Serum Uric Acid Is Associated With Gut Microbiota in Patients With Diabetes Mellitus.

Front Cell Infect Microbiol. 2021

[2]
Relationship between the Gut Microbiome and Osteoarthritis Pain: Review of the Literature.

Nutrients. 2021-2-24

[3]
Metabolic signatures of osteoarthritis in urine using liquid chromatography-high resolution tandem mass spectrometry.

Metabolomics. 2021-3-3

[4]
Understanding the binding mechanism of succinic acid against phospholipase A from bee venom.

J Biochem Mol Toxicol. 2021-4

[5]
Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway.

Int Immunopharmacol. 2021-1

[6]
Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats.

Drug Des Devel Ther. 2020

[7]
Persistent metabolomic alterations characterize chronic critical illness after severe trauma.

J Trauma Acute Care Surg. 2021-1-1

[8]
Colchicine increases intestinal permeability, suppresses inflammatory responses, and alters gut microbiota in mice.

Toxicol Lett. 2020-9-28

[9]
Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment.

Drug Deliv Transl Res. 2021-6

[10]
Short chain fatty acids in human gut and metabolic health.

Benef Microbes. 2020-9-1

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