Musculoskeletal Pain and Motor Control Research Group, Faculty of Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain.
Department of Physiotherapy, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Tajo, s/n, Urbanización El Bosque, Villaviciosa de Odón, 28670 Madrid, Spain.
Nutrients. 2021 Feb 24;13(3):716. doi: 10.3390/nu13030716.
Osteoarthritis (OA) is the most common form of chronic pain in Europe (34%), representing a great economic and social cost to society. There are studies that suggest an intestine-brain-articulation axis and hint at the existence of low-grade intestinal inflammation in OA, which would be related to an alteration of the microbiota and to the impairment of the epithelial barrier, with leakage of the microbial components.
The purpose of this study was to review the association between gut microbiome and pain in the OA population through a review of the literature.
A literature search was conducted to identify all available studies on the association between the gut microbiome and pain in the OA population, with no publication date limit until September 2020 and no language limit, in the MEDLINE, CINAHL, Web of Science and Cochrane Central Register of Controlled Trials databases.
Only three of 2084 studies detected and analyzed by performing the proposed searches in the detailed databases, were finally selected for this review, of which one was with and two were without intervention. These studies only weakly support a relationship between the gut microbiome and OA, specifically a correlation between certain taxa or microbial products and the inflammatory landscape and severity of OA symptoms, including knee pain. Conclusions Despite encouraging results, this review highlights the paucity of high-quality studies addressing the potential role of the gut microbiome in OA-related pain, along with the disparity of the techniques used so far, making it impossible to draw firm conclusions on the topic.
骨关节炎（OA）是欧洲最常见的慢性疼痛形式（34%），给社会带来了巨大的经济和社会成本。有研究表明存在肠-脑-关节轴，并暗示 OA 中存在低水平的肠道炎症，这与微生物群的改变和上皮屏障的损伤有关，微生物成分会泄漏。
本研究通过文献回顾，旨在探讨肠道微生物群与 OA 人群疼痛之间的关系。
对 MEDLINE、CINAHL、Web of Science 和 Cochrane 中央对照试验注册库中的所有关于肠道微生物群与 OA 人群疼痛之间关联的现有研究进行了文献检索，无发表日期限制，截至 2020 年 9 月，也无语言限制。
在所进行的详细数据库搜索中，从 2084 项研究中仅检测和分析了三项，最终被选为本次综述的研究，其中一项为干预性研究，两项为非干预性研究。这些研究仅微弱地支持肠道微生物群与 OA 之间存在关系，特别是某些分类群或微生物产物与 OA 症状的炎症状况和严重程度之间存在相关性，包括膝关节疼痛。结论：尽管结果令人鼓舞，但本次综述强调了高质量研究的缺乏，这些研究涉及肠道微生物群在 OA 相关疼痛中的潜在作用，以及迄今为止使用的技术差异，使得不可能就这一主题得出确凿的结论。
