Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.
Immunol Rev. 2022 Oct;311(1):177-186. doi: 10.1111/imr.13123. Epub 2022 Aug 4.
Behavior and cognition are multifaceted processes influenced by genetics, synaptic plasticity, and neuronal connectivity. Recent reports have demonstrated that peripheral inflammation and peripheral immune cells play important roles in the preservation and deterioration of behavior/cognition under various conditions. Indeed, several studies show that the activity of peripheral immune cells can be critical for normal cognitive function. Neutrophils are the most abundant immune cells in the mammalian system. Their activation is critical to the initiation of the inflammatory process and critical for wound healing. Neutrophils are the first cells to be activated and recruited to the central nervous system in both injury and disease. However, our understanding of the role these cells play in behavior and cognition is limited. The present review will summarize what is currently known about the effect the activation of these cells has on various behaviors and cognitive processes.
行为和认知是受遗传、突触可塑性和神经元连接影响的多方面过程。最近的报告表明，在各种情况下，外周炎症和外周免疫细胞在行为/认知的维持和恶化中起着重要作用。事实上，有几项研究表明，外周免疫细胞的活性对于正常的认知功能至关重要。中性粒细胞是哺乳动物系统中最丰富的免疫细胞。它们的激活对于炎症过程的启动至关重要，并且对于伤口愈合也很关键。中性粒细胞是在损伤和疾病中第一个被激活并募集到中枢神经系统的细胞。然而，我们对这些细胞在行为和认知中所起作用的理解是有限的。本综述将总结目前已知的这些细胞的激活对各种行为和认知过程的影响。
