Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Department of Renal Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Clin Cardiol. 2022 Sep;45(9):908-912. doi: 10.1002/clc.23834. Epub 2022 Aug 4.
Lipoprotein(a) [Lp(a)] is associated with coronary atherosclerotic heart disease, aortic stenosis, stroke, and heart failure. We aimed to determine the relationship between Lp(a) and aortic dissection (AD).
Two hundred patients with AD were included in our case group. The control group consisted of 200 non-AD people who were age- (±5 years) and gender-matched to the case group. Data were collected retrospectively, including hypertension, smoking, coronary artery disease, diabetes mellitus, Lp(a), total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. The association between Lp(a) and AD was studied using univariate and multivariate logistic regression analysis.
Patients with AD had greater median Lp(a) concentrations than non-AD people (152.50 vs. 81.75 mg/L). Lp(a) was associated with AD in a multivariate logistic regression analysis (odds ratio, 8.03; 95% confidence interval, 2.85-22.62), comparing those with Lp(a) quartile 4 with those with Lp(a) quartile 1. Stratified analysis showed that this relationship was observed in both men and women, as well as in older and younger individuals.
High levels of Lp(a) are strongly associated with AD, independent of other cardiovascular risk factors.
脂蛋白(a)[Lp(a)]与冠状动脉粥样硬化性心脏病、主动脉瓣狭窄、中风和心力衰竭有关。我们旨在确定 Lp(a)与主动脉夹层(AD)之间的关系。
我们的病例组纳入了 200 名 AD 患者。对照组由 200 名非 AD 患者组成，与病例组的年龄(±5 岁)和性别相匹配。数据是回顾性收集的，包括高血压、吸烟、冠心病、糖尿病、Lp(a)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇。使用单变量和多变量逻辑回归分析研究 Lp(a)与 AD 之间的关系。
AD 患者的 Lp(a)中位数浓度高于非 AD 患者(152.50 vs. 81.75mg/L)。在多变量逻辑回归分析中，Lp(a)与 AD 相关(比值比，8.03；95%置信区间，2.85-22.62)，将 Lp(a)四分位 4 与 Lp(a)四分位 1 进行比较。分层分析表明，这种关系在男性和女性以及年龄较大和较小的个体中均存在。
高水平的 Lp(a)与 AD 密切相关，独立于其他心血管危险因素。
