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脂蛋白（a）及其基因变异对心血管的影响：来自中东的批判性综述

Cardiovascular Implications of Lipoprotein(a) and its Genetic Variants: A Critical Review From the Middle East.

作者信息

El-Menyar Ayman, Khan Naushad A, Al Mahmeed Wael, Al Suwaidi Jassim, Al-Thani Hassan

机构信息

Clinical Research, Vascular Surgery, Hamad Medical Corporation, Doha, Qatar; Clinical Medicine, Weill Cornell Medicine, Doha, Qatar.

Clinical Research, Vascular Surgery, Hamad Medical Corporation, Doha, Qatar.

出版信息

JACC Asia. 2025 Jul;5(7):847-864. doi: 10.1016/j.jacasi.2025.04.012.

DOI:10.1016/j.jacasi.2025.04.012
PMID:40610121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12277198/
Abstract

Dyslipidemia, a significant risk factor for cardiovascular diseases (CVDs), is prevalent in the Middle East (ME) countries. With a variable prevalence, elevated lipoprotein (a) [Lp(a)] is the most widespread monogenic dyslipidemic disorder. Genetic studies have established Lp(a) as a heritable and independent risk factor for CVD. This discovery has shifted the perception of Lp(a) and the LPA gene from mere biomarkers of atherosclerotic risk to a viable target for therapeutic intervention. Significant differences in serum Lp(a) levels have been observed across racial and ethnic groups, with few independent genetic variants affecting Lp(a) levels outside the LPA gene region. Data specific to the ME and Arab populations remains scarce. ME populations exhibit genetic diversity and higher consanguinity rates, which may uniquely influence Lp(a) distribution and associated variations. This review examines the genetic and observational factors that shape Lp(a) levels and their role in CVD risk, focusing on ME populations.

摘要

血脂异常是心血管疾病（CVD）的一个重要危险因素，在中东（ME）国家普遍存在。脂蛋白（a）[Lp（a）]升高是最常见的单基因血脂异常疾病，其患病率各不相同。基因研究已将Lp（a）确立为CVD的遗传和独立危险因素。这一发现已将对Lp（a）和LPA基因的认识从动脉粥样硬化风险的单纯生物标志物转变为治疗干预的可行靶点。不同种族和民族的血清Lp（a）水平存在显著差异，在LPA基因区域之外，几乎没有影响Lp（a）水平的独立基因变异。关于中东和阿拉伯人群的具体数据仍然很少。中东人群表现出遗传多样性和较高的近亲结婚率，这可能会独特地影响Lp（a）的分布及相关变异。本综述探讨了影响Lp（a）水平的遗传和观察因素及其在CVD风险中的作用，重点关注中东人群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/35f90f821ff1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/ba3627a9688f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/ba3627a9688f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/77f4008034c9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/2d5572b978f0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/ff8c7cafbbc1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/35f90f821ff1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/ba3627a9688f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/ba3627a9688f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/77f4008034c9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/2d5572b978f0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/ff8c7cafbbc1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/12277198/35f90f821ff1/gr4.jpg

相似文献

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[5]
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[10]
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本文引用的文献

[1]
Cardiovascular disease burden in the North Africa and Middle East region: an analysis of the global burden of disease study 1990-2021.

BMC Cardiovasc Disord. 2024-12-19

[2]
The influence of lipoprotein(a) on aortic valve calcification in patients undergoing transcatheter aortic valve replacement.

Clin Res Cardiol. 2025-3

[3]
Association of Lipoprotein(a) With Severe Degenerative Aortic Valve Stenosis.

JACC Asia. 2024-9-10

[4]
Lipoprotein (a) Testing in Patients With Atherosclerotic Cardiovascular Disease in 5 Large US Health Systems.

J Am Heart Assoc. 2024-11-5

[5]
Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk.

BMC Med Genomics. 2024-10-24

[6]
Analyzing Cardiovascular Disease Research in the Arab Region: A Bibliometric Review From 2012 to 2022.

Int J Vasc Med. 2024-10-12

[7]
Genetic Biomarkers in Heart Failure: From Gene Panels to Polygenic Risk Scores.

Curr Heart Fail Rep. 2024-12

[8]
Mendelian Randomization Studies in Atherosclerotic Cardiovascular Diseases.

J Lipid Atheroscler. 2024-9

[9]
Lipoprotein(a) and cardiovascular disease.

Lancet. 2024-9-28

[10]
Is There a Need for Sex-Tailored Lipoprotein(a) Cut-Off Values for Coronary Artery Disease Risk Stratification?

Clin Cardiol. 2024-9

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