肥胖治疗期间维生素E状态的变化。

Changes in vitamin E status during obesity treatment.

作者信息

Vandewoude M G, Van Gaal L, De Leeuw I

出版信息

Ann Nutr Metab. 1987;31(3):185-90. doi: 10.1159/000177267.

Abstract

The effects of vitamin E on platelet function and erythrocyte membrane rigidity are extensively described. Little is known, however, about the vitamin E status in an obese population and about the effect of weight loss on it. This study evaluates the changes in vitamin E status during obesity treatment in 8 morbidly obese females. They received a protein-sparing modified fast (PSMF) diet for a period of 5 weeks; mean vitamin E supplementation did not exceed the recommended daily allowance (8 mg of alpha-tocopherol equivalents). During the investigated period plasma vitamin E levels increased (p less than 0.02), while there was a slight decrease in plasma cholesterol. The rise in total tocopherol/total cholesterol ratio was highly significant (p less than 0.002). Both the experimental design and the results are comparable with previously reported data in hypothalamic obese mice. It is, therefore, suggested that the hypothalamic obese mouse is a convenient animal model for the study of vitamin E nutritional status in obesity.

摘要

维生素E对血小板功能和红细胞膜刚性的影响已有广泛描述。然而，关于肥胖人群的维生素E状态以及体重减轻对其的影响却知之甚少。本研究评估了8名病态肥胖女性在肥胖治疗期间维生素E状态的变化。她们接受了为期5周的蛋白质节省改良禁食（PSMF）饮食；平均维生素E补充量未超过推荐每日摄入量（8毫克α-生育酚当量）。在研究期间，血浆维生素E水平升高（p<0.02），而血浆胆固醇略有下降。总生育酚/总胆固醇比值的升高非常显著（p<0.002）。实验设计和结果均与先前报道的下丘脑肥胖小鼠的数据具有可比性。因此，有人提出下丘脑肥胖小鼠是研究肥胖中维生素E营养状况的便捷动物模型。