St. Johns Medical College and Hospital, Bengaluru, Karnataka, India.
Department of Internal Medicine, St. Johns Medical College and Hospital, Bengaluru, Karnataka, India.
Diabetes Metab Syndr. 2022 Aug;16(8):102568. doi: 10.1016/j.dsx.2022.102568. Epub 2022 Jul 19.
Painful diabetic peripheral neuropathy (PDPN) is a common complication of type 2 diabetes. The unrelenting pain associated with PDPN adversely affects a patient's quality of life. Recognizing the crucial role that sleep plays in the metabolic control of diabetes, this study aims to estimate the prevalence of sleep impairment in painful diabetic peripheral neuropathy (PDPN) and identify the factors associated with it.
We conducted a cross-sectional study among 156 patients in a tertiary care hospital in south India. We recruited consenting adults with PDPN. Sleep quality was analyzed using the Pittsburg sleep quality index (PSQI), a self-rating scale. Hba1c served as a measure of glycemic control. Anxiety and depression were assessed using the hospital anxiety and depression (HAD) scale. Data were analyzed in SPSS 26.0.
A total of 156 patients were included in the study with a mean age of 58.39 ± 9.12 years. In 151 (96.79%) patients demonstrated sleep impairment with a global PSQI score of 10.92 ± 2.87. Female sex, ischemic heart disease (IHD), high anxiety levels and use of insulin, pregabapentin, and duloxetine; were significantly associated with poor sleep quality (p < 0.05). The median Hba1c was high (9% [7.46-11.1]). However, there was no statistical correlation between the degree of sleep impairment and glycemic control.
We found a high prevalence of sleep impairment in patients with PDPN. Female sex, IHD, high anxiety levels and use of neuropathic drugs were predictors of poor sleep quality.
疼痛性糖尿病周围神经病变（PDPN）是 2 型糖尿病的常见并发症。与 PDPN 相关的持续性疼痛会对患者的生活质量产生不利影响。鉴于睡眠对糖尿病代谢控制的重要作用，本研究旨在评估疼痛性糖尿病周围神经病变（PDPN）患者睡眠障碍的发生率，并确定与睡眠障碍相关的因素。
我们在印度南部的一家三级保健医院进行了一项横断面研究。我们招募了同意参加的 PDPN 成年患者。使用匹兹堡睡眠质量指数（PSQI），一种自评量表来分析睡眠质量。糖化血红蛋白（HbA1c）作为血糖控制的衡量标准。使用医院焦虑和抑郁量表（HAD）评估焦虑和抑郁。数据在 SPSS 26.0 中进行分析。
共有 156 例患者纳入研究，平均年龄为 58.39±9.12 岁。在 151 例（96.79%）患者中，PSQI 总分 10.92±2.87，存在睡眠障碍。女性、缺血性心脏病（IHD）、高焦虑水平以及使用胰岛素、普瑞巴林和度洛西汀与睡眠质量差显著相关（p<0.05）。中位糖化血红蛋白水平较高（9%[7.46-11.1]）。然而，睡眠障碍程度与血糖控制之间无统计学相关性。
我们发现 PDPN 患者睡眠障碍的发生率较高。女性、IHD、高焦虑水平以及使用神经病理性药物是睡眠质量差的预测因素。
