二十年后城市县医院对乙酰氨基酚用药过量的流行病学变化。
Changes in Epidemiology of Acetaminophen Overdoses in an Urban County Hospital After 20 Years.
机构信息
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
NYU Langone Medical Center, New York, New York, USA.
出版信息
Am J Gastroenterol. 2022 Aug 1;117(8):1324-1328. doi: 10.14309/ajg.0000000000001826. Epub 2022 May 5.
INTRODUCTION
Acetaminophen (APAP) toxicity is the main cause of acute liver failure in the United States. A prior series (1992-1995) identified 71 hospitalized adults with APAP toxicity through the International Statistical Classification of Disease and Related Health Problems, 9th revision (ICD-9) code at Parkland Hospital, Dallas, TX.
METHODS
We used a laboratory database search of serum APAP levels from 2011 to 2015 to identify patients with APAP toxicity in the same hospital.
RESULTS
We identified 140 patients hospitalized for APAP toxicity from 27,143 APAP levels obtained; 35 required Intensive Care Unit (ICU) admission, and there were no deaths. APAP toxicity/100,000 admissions was similar between eras.
DISCUSSION
APAP toxicity continues unabated after 20 years but with improved overall outcomes.
引言
对乙酰氨基酚（APAP）中毒是美国急性肝衰竭的主要原因。先前的一项研究（1992-1995 年）通过德克萨斯州达拉斯市帕克兰医院的国际疾病分类与相关健康问题第 9 版（ICD-9）代码确定了 71 名住院的成人 APAP 中毒患者。
方法
我们使用实验室数据库搜索 2011 年至 2015 年的血清 APAP 水平，以确定同一医院的 APAP 中毒患者。
结果
我们从 27143 个 APAP 水平中确定了 140 名因 APAP 中毒住院的患者；35 名需要入住重症监护病房（ICU），但无死亡病例。两个时期的 APAP 中毒/每 10 万例入院率相似。
讨论
20 年后，APAP 中毒仍在继续，但整体预后有所改善。
Zotero 插件