College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, China.
Int J Biol Macromol. 2022 Oct 31;219:1009-1020. doi: 10.1016/j.ijbiomac.2022.07.212. Epub 2022 Aug 1.
Vancomycin (Van) remains one of the first-line drugs for the treatment of wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA). However, the unsatisfactory bioavailability of vancomycin alone has greatly limited its potential health benefits. Here a responsive chitosan-based hydrogel was developed as the delivery system which not only would reduce this side effect but also increase efficacy of vancomycin. The hydrogel was prepared by grafting chitosan and cinnamaldehyde-based thioacetal (CTA) together with ginipin (G) as the crosslinker. Upon exposure to reactive oxygen species which were enriched in the bacterial wound, the hydrogel can locally degrade and sustainably release the loaded vancomycin near the lesion to compete with the troubling MRSA. Compared with vancomycin alone, the chitosan-based hydrogel loaded with vancomycin demonstrated accelerated acute wound healing. This achievement reveals that this multi-functional hydrogel may be a promising drug-delivery device for improving the efficacy of local antibiotic therapy.
万古霉素（Van）仍然是治疗耐甲氧西林金黄色葡萄球菌（MRSA）引起的伤口感染的一线药物之一。然而，万古霉素单独使用时生物利用度不理想，极大地限制了其潜在的健康益处。在这里，开发了一种响应性壳聚糖基水凝胶作为递送系统，不仅可以减少这种副作用，还可以提高万古霉素的疗效。该水凝胶是通过将壳聚糖与肉桂醛基硫缩醛（CTA）与金纳米酶（G）一起接枝制备的，作为交联剂。当暴露于富含在细菌伤口中的活性氧时，水凝胶可以在局部降解，并在病变部位附近持续释放负载的万古霉素，以与令人困扰的 MRSA 竞争。与单独使用万古霉素相比，负载万古霉素的壳聚糖基水凝胶表现出加速急性伤口愈合的效果。这一成就表明，这种多功能水凝胶可能是一种有前途的药物递送装置，可提高局部抗生素治疗的疗效。
