Li Yaqin, Lu Jianping, Shi Jingru, Zhang Lingjiao, Mu Haibo, Cui Tong
Xinjiang Xinhe Zhitong Technology Service Co. Ltd., Urumqi, China.
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Front Bioeng Biotechnol. 2024 Sep 20;12:1429771. doi: 10.3389/fbioe.2024.1429771. eCollection 2024.
The simultaneous administration of antibacterial treatment and acceleration of tissue regeneration are crucial for the effective healing of infected wounds. In this work, we developed a facile hydrogel (PCC hydrogel) through coordination and hydrogen interactions by polymerizing acrylamide monomers in the presence of carboxymethyl chitosan nanoparticles and copper ions. The prepared PCC hydrogel demonstrated effective bacterial capture from wound exudation and exhibited a potent bactericidal activity against methicillin-resistant (MRSA) and . Furthermore, slow release of copper ions from the hydrogel facilitated wound healing by promoting cell migration, collagen deposition and angiogenesis. Additionally, the PCC hydrogel possessed excellent biocompatibility and hemostatic properties. The practical effectiveness of PCC hydrogel in addressing bacterial infections and facilitating wound healing was verified using a mouse model of MRSA-induced wound infections. Overall, this work presents a simple yet efficient multifunctional hydrogel platform that integrates antibacterial activity, promotion of wound healing, and hemostasis for managing bacteria-associated wounds.
同时进行抗菌治疗和加速组织再生对于感染伤口的有效愈合至关重要。在这项工作中，我们通过在羧甲基壳聚糖纳米颗粒和铜离子存在下聚合丙烯酰胺单体，通过配位和氢键相互作用开发了一种简便的水凝胶（PCC水凝胶）。制备的PCC水凝胶显示出能有效从伤口渗出物中捕获细菌，并对耐甲氧西林金黄色葡萄球菌（MRSA）表现出强大的杀菌活性。此外，水凝胶中铜离子的缓慢释放通过促进细胞迁移、胶原蛋白沉积和血管生成来促进伤口愈合。此外，PCC水凝胶具有优异的生物相容性和止血性能。使用MRSA诱导的伤口感染小鼠模型验证了PCC水凝胶在解决细菌感染和促进伤口愈合方面的实际有效性。总体而言，这项工作提出了一个简单而高效的多功能水凝胶平台，该平台整合了抗菌活性、促进伤口愈合和止血功能，用于处理与细菌相关的伤口。
