Nishio M, Sakurai T, Kagami Y, Narimatsu N
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 2):1519-30.
Brachytherapy is one of most effective methods of radiotherapy for cancer, and therefore, low-dose-rate brachytherapy is widely used for carcinoma of the uterus and carcinoma of the tongue. Between 1974 and 1983, 76 primary thoracic esophageal squamous cell carcinomas were treated with external irradiation combined with additional intracavitary radium therapy at the National Sapporo Hospital. The esophageal primary control rate was 34% and the 5-year survival rate was 24.1%. We believe that external irradiation therapy followed by additional intracavitary radium irradiation produces good results. Also, from 1982, 30 patients with small residual or unresectable tumors received interstitial irradiation using an after-loading technique and iridium-192 seeds. Eighteen of these 30 patients treated with iridium-192 were recurrent cases, and 20 had outer tubes intra-operatively inserted into the tumor following iridium-192 irradiation. Ten of these patients had brain tumor, nine had cancer of the head and neck, and each of the remaining fifteen had the following malignancies: lung cancer, breast cancer, pancreatic cancer, bile duct cancer, uterus cancer, skin cancer and soft tissue sarcoma. Overall 4-year survival was 17.1% in among the patients treated with Ir 192. Favorable preliminary results from these patients and those of various clinical trials on the extension of indications for brachytherapy were also reported.
近距离放射治疗是癌症放射治疗中最有效的方法之一，因此，低剂量率近距离放射治疗广泛应用于子宫癌和舌癌。1974年至1983年间，札幌国立医院对76例原发性胸段食管鳞状细胞癌患者进行了外照射联合腔内镭疗。食管原发灶控制率为34%，5年生存率为24.1%。我们认为，外照射后加腔内镭照射可取得良好效果。此外，从1982年起，30例有小的残留或不可切除肿瘤的患者采用后装技术和铱-192籽源进行了组织间照射。这30例接受铱-192治疗的患者中有18例为复发病例，20例在铱-192照射后术中在外肿瘤内插入外管。其中10例患者患有脑肿瘤，9例患有头颈部癌，其余15例分别患有以下恶性肿瘤：肺癌、乳腺癌、胰腺癌、胆管癌、子宫癌、皮肤癌和软组织肉瘤。接受铱-192治疗的患者4年总生存率为17.1%。还报告了这些患者的良好初步结果以及关于扩大近距离放射治疗适应证的各种临床试验的结果。
