Beppu Y, Fukuma H, Chuma H, Ise T, Ohira M
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 2):1603-13.
Seventy-nine patients with rhabdomyosarcoma (RMS) received treatment at the National Cancer Center Hospital between 1962 and 1985. The patients ranged in age from 4 months to 74 years with a median age of 6 years. Forty-six patients were male and 33 were female. The primary tumor site of RMS was the same as in the previous report. The head and neck region was the most frequent site (40.5%), followed by the extremities (34.1%), genitourinary region (15.2%), trunk (5.1%) and retroperitoneum (5.1%). Histologic types were embryonal RMS in 45 patients, alveolar RMS in 23 patients, pleomorphic RMS in 8 patients and unclassified RMS in 3 patients. As of October 1985, 14 of the 79 patients were still alive. Between 1962 and 1971, 38 patients were not treated by any protocol. After 1972, 41 patients received treatment using a 3 stage-related, multiple-modality program. In the first protocol, chemotherapy consisted of Vincristine, Cyclophosphamide, and Actinomycin-D, and 1 of 18 patients have survived more than 5 years. The cumulative 5-year survival rate of the first protocol was 11.1%. In the second treatment program, which involved Adriamycin in addition to the 3 drugs cited above, 4 of 23 patients have survived more than 5 years. The cumulative 5-year survival rate, 33.2%, was very improved.
1962年至1985年间，79例横纹肌肉瘤（RMS）患者在国立癌症中心医院接受了治疗。患者年龄从4个月至74岁不等，中位年龄为6岁。46例为男性，33例为女性。RMS的原发肿瘤部位与之前的报告相同。头颈部是最常见的部位（40.5%），其次是四肢（34.1%）、泌尿生殖系统（15.2%）、躯干（5.1%）和腹膜后（5.1%）。组织学类型为胚胎型RMS 45例，肺泡型RMS 23例，多形性RMS 8例，未分类RMS 3例。截至1985年10月，79例患者中有14例仍存活。1962年至1971年，38例患者未接受任何方案治疗。1972年后，41例患者采用了与3个阶段相关的多模式方案进行治疗。在第一个方案中，化疗由长春新碱、环磷酰胺和放线菌素-D组成，18例患者中有1例存活超过5年。第一个方案的累积5年生存率为11.1%。在第二个治疗方案中，除上述3种药物外还加入了阿霉素，23例患者中有4例存活超过5年。累积5年生存率为33.2%，有了很大提高。
