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喉癌的多学科治疗

[Multidisciplinary treatment of carcinoma of the larynx].

作者信息

Yoshino K

出版信息

Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 1):1812-9.

PMID:3592716
Abstract

The prognosis of the laryngeal carcinoma is better than that of other head and neck carcinomas. The five-year survival rate ranges between 70 and 80%. The proportion of cases of early glottic carcinoma has increased at our clinic. In 1986, about 70% of all laryngeal carcinomas were glottic carcinoma, and about half of these were early-stage cases. The principle of management is, primarily, life-saving and then functional preservation. For this purpose, it is mandatory to make an exact diagnosis and to treat the condition appropriately. Generally, the modality of treatment is mainly radiation and surgery; radiation or partial laryngectomy for early-stage cancer, total laryngectomy for advanced-stage cancer. However, selection of therapy should not only be based on stage, but also on various other factors, e.g., type of growth, medical facilities available and the patient's situation (age, etc.). Recently, laser therapy has been tried for early carcinoma. Patients with advanced carcinoma still have a poor prognosis, and so planned combined therapy including chemotherapy and immunotherapy should be considered. Vocal rehabilitation following total laryngectomy is also very important. There are three main methods of rehabilitation, i.e., esophageal speech, artificial larynx (pneumatic larynx or electro-larynx) and surgery (reconstructive laryngectomy, tracheoesophageal shunt).

摘要

喉癌的预后优于其他头颈癌。五年生存率在70%至80%之间。在我们诊所,早期声门癌的病例比例有所增加。1986年,所有喉癌病例中约70%为声门癌,其中约一半为早期病例。治疗原则首先是挽救生命,其次是保留功能。为此,必须做出准确诊断并进行适当治疗。一般来说,治疗方式主要是放疗和手术;早期癌症采用放疗或部分喉切除术,晚期癌症采用全喉切除术。然而,治疗方法的选择不仅应基于分期,还应基于各种其他因素,例如生长类型、可用的医疗设施以及患者的情况(年龄等)。最近,已尝试对早期癌采用激光治疗。晚期癌患者的预后仍然很差,因此应考虑包括化疗和免疫疗法在内的计划性联合治疗。全喉切除术后的嗓音康复也非常重要。有三种主要的康复方法,即食管言语、人工喉(气动喉或电子喉)和手术(重建喉切除术、气管食管分流术)。

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