子宫内膜容受性基因的表达模式在子宫内膜和匹配的子宫内膜异位症之间不同步。

The expression pattern of endometrial receptivity genes is desynchronized between endometrium and matched endometriomas.

机构信息

Competence Centre on Health Technologies Tartu, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu Tartu, Estonia.

出版信息

Reprod Biomed Online. 2022 Oct;45(4):713-720. doi: 10.1016/j.rbmo.2022.05.028. Epub 2022 Jun 9.

DOI:10.1016/j.rbmo.2022.05.028

PMID:35927210

Abstract

RESEARCH QUESTION

Are paired samples of endometrium and ovarian endometriomas synchronous with each other throughout the menstrual cycle?

DESIGN

The expression levels of 57 endometrial receptivity-associated genes were determined from matched endometrial and endometrioma samples (n=31) collected from women with endometriosis throughout the menstrual cycle.

RESULTS

The expression profile of endometrial receptivity genes divided endometrial samples according to their menstrual cycle phase. Endometrioma samples grouped together irrespective of the menstrual cycle phase and formed a cluster distinct from endometrial samples. Pairwise comparison showed 21, 16, 33 and 23 differentially expressed genes (adjusted P < 0.001-0.05) between the lesions and endometria collected in the proliferative, early-secretory, mid-secretory and late-secretory menstrual cycle phases, respectively, confirming the distinct expression profiles of endometrium and endometrioma.

CONCLUSIONS

No menstrual cycle synchronicity was found between matched eutopic and ectopic endometrium, suggesting that the concept of cycling endometrial tissue inside the endometrioma should be revised.

摘要

研究问题

子宫内膜和卵巢子宫内膜异位症的配对样本在整个月经周期中是否同步？

设计

从患有子宫内膜异位症的女性在整个月经周期中采集的 31 对子宫内膜和子宫内膜异位症样本（n=31）中确定了 57 个与子宫内膜容受性相关的基因的表达水平。

结果

子宫内膜容受性基因的表达谱根据月经周期阶段将子宫内膜样本进行了分类。子宫内膜异位症样本无论月经周期阶段如何都聚集在一起，并形成了与子宫内膜样本不同的聚类。两两比较显示，在增殖期、早期分泌期、中期分泌期和晚期分泌期采集的病变和子宫内膜之间分别有 21、16、33 和 23 个差异表达基因（调整后的 P 值 < 0.001-0.05），证实了子宫内膜和子宫内膜异位症的明显不同的表达谱。