Igarashi Masaki, Nakagawa-Nagahama Yoshiko, Miura Masaomi, Kashiwabara Kosuke, Yaku Keisuke, Sawada Mika, Sekine Rie, Fukamizu Yuichiro, Sato Toshiya, Sakurai Takanobu, Sato Jiro, Ino Kenji, Kubota Naoto, Nakagawa Takashi, Kadowaki Takashi, Yamauchi Toshimasa
Department of Diabetes & Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Data Science Office, Clinical Research Promotion Center, The University of Tokyo Hospital, Tokyo, Japan.
NPJ Aging. 2022 May 1;8(1):5. doi: 10.1038/s41514-022-00084-z.
Preclinical studies have revealed that the elevation of nicotinamide adenine dinucleotide (NAD + ) upon the administration of nicotinamide mononucleotide (NMN), an NAD + precursor, can mitigate aging-related disorders; however, human data on this are limited. We investigated whether the chronic oral supplementation of NMN can elevate blood NAD + levels and alter physiological dysfunctions in healthy older participants. We administered 250 mg NMN per day to aged men for 6 or 12 weeks in a placebo-controlled, randomized, double-blind, parallel-group trial. Chronic NMN supplementation was well tolerated and caused no significant deleterious effect. Metabolomic analysis of whole blood samples demonstrated that oral NMN supplementation significantly increased the NAD + and NAD + metabolite concentrations. There were nominally significant improvements in gait speed and performance in the left grip test, which should be validated in larger studies; however, NMN exerted no significant effect on body composition. Therefore, chronic oral NMN supplementation can be an efficient NAD + booster for preventing aging-related muscle dysfunctions in humans.
临床前研究表明，烟酰胺单核苷酸（NMN）作为烟酰胺腺嘌呤二核苷酸（NAD⁺）的前体，给药后NAD⁺水平的升高可减轻与衰老相关的疾病；然而，关于这方面的人体数据有限。我们研究了长期口服补充NMN是否能提高健康老年参与者的血液NAD⁺水平并改善生理功能障碍。在一项安慰剂对照、随机、双盲、平行组试验中，我们每天给老年男性服用250毫克NMN，持续6周或12周。长期补充NMN耐受性良好，未产生明显有害影响。全血样本的代谢组学分析表明，口服NMN补充剂显著提高了NAD⁺和NAD⁺代谢物的浓度。在步态速度和左手握力测试表现方面有名义上的显著改善，这需要在更大规模的研究中得到验证；然而，NMN对身体成分没有显著影响。因此，长期口服补充NMN可能是一种有效的NAD⁺增强剂，可预防人类与衰老相关的肌肉功能障碍。
