University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Case Western Reserve University, Cleveland, OH, USA.
J Perinatol. 2022 Nov;42(11):1480-1484. doi: 10.1038/s41372-022-01471-w. Epub 2022 Aug 4.
To determine the association between human milk exposure at 3 months corrected gestational age and recurrent wheeze in preterm Black infants.
This is a secondary analysis of data from the D-Wheeze trial (ClinicalTrials.gov identifier NCT01601847). Associations between human milk feeding at 3 months corrected age and wheezing outcomes were examined by generalized linear models.
Exclusively human milk fed infants (n = 13) had significantly fewer wheezing episodes than formula fed infants (n = 230) (IRR (95% CI) = 0.25 (0.07, 0.89), p = 0.03). There were no hospitalizations in infants receiving exclusive human milk. Receiving any human milk was associated with decreased odds of hospitalization by 12 months corrected age (OR (95% CI) = 0.12 (0.02, 0.79), p = 0.03).
Exclusive human milk feeding at three months corrected gestational age is associated with decreased number of wheezing episodes in the first year of life in preterm Black infants.
确定 3 个月校正胎龄时人乳暴露与早产黑人婴儿反复喘息的关系。
这是 D-Wheeze 试验（ClinicalTrials.gov 标识符 NCT01601847）数据的二次分析。通过广义线性模型检查 3 个月校正年龄时人乳喂养与喘息结局之间的关联。
纯母乳喂养婴儿（n=13）的喘息发作次数明显少于配方奶喂养婴儿（n=230）（IRR（95%CI）=0.25（0.07,0.89），p=0.03）。接受纯母乳喂养的婴儿无一例住院。接受任何人乳喂养与 12 个月校正年龄时住院的几率降低相关（OR（95%CI）=0.12（0.02,0.79），p=0.03）。
在 3 个月校正胎龄时进行纯母乳喂养与早产黑人婴儿生命第一年喘息发作次数减少有关。
