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Impact of Delayed Neoadjuvant Systemic Chemotherapy on Overall Survival Among Patients with Breast Cancer.新辅助化疗延迟对乳腺癌患者总生存的影响。
Oncologist. 2020 Sep;25(9):749-757. doi: 10.1634/theoncologist.2019-0744. Epub 2020 Jul 7.
2
Breast cancer incidence and mortality before and after implementation of the German mammography screening program.德国乳腺 X 光筛查项目实施前后的乳腺癌发病与死亡情况。
Int J Cancer. 2020 Aug 1;147(3):709-718. doi: 10.1002/ijc.32767. Epub 2019 Dec 4.
3
Effect of Surgery Type on Time to Adjuvant Chemotherapy and Impact of Delay on Breast Cancer Survival: A National Cancer Database Analysis.手术类型对辅助化疗时间的影响及延迟对乳腺癌生存的影响:国家癌症数据库分析。
Ann Surg Oncol. 2019 Oct;26(10):3240-3249. doi: 10.1245/s10434-019-07566-7. Epub 2019 Jul 22.
4
Timing and Delays in Breast Cancer Evaluation and Treatment.乳腺癌评估和治疗中的时间和延误。
Ann Surg Oncol. 2018 Oct;25(10):2829-2838. doi: 10.1245/s10434-018-6615-2. Epub 2018 Jul 2.
5
Effects of age on the detection and management of breast cancer.年龄对乳腺癌检测与管理的影响。
Cancers (Basel). 2015 May 22;7(2):908-29. doi: 10.3390/cancers7020815.
6
Quality of care in breast cancer centers: results of benchmarking by the German Cancer Society and German Society for Breast Diseases.乳腺癌中心的医疗质量:德国癌症协会和德国乳腺疾病协会的基准化评估结果
Breast. 2015 Apr;24(2):118-23. doi: 10.1016/j.breast.2014.11.014. Epub 2014 Dec 13.
7
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.全球癌症发病与死亡:GLOBOCAN 2012 数据源、方法与主要模式。
Int J Cancer. 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210. Epub 2014 Oct 9.
8
Stage at breast cancer diagnosis and distance from diagnostic hospital in a periurban setting: a South African public hospital case series of over 1,000 women.在城郊环境中,乳腺癌诊断时的分期和与诊断医院的距离:南非一家公立医院超过 1000 名女性的病例系列。
Int J Cancer. 2014 Nov 1;135(9):2173-82. doi: 10.1002/ijc.28861. Epub 2014 Apr 7.
9
Cancer statistics, 2014.癌症统计数据,2014 年。
CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29. doi: 10.3322/caac.21208. Epub 2014 Jan 7.
10
Delays in diagnosis and treatment of breast cancer: a multinational analysis.乳腺癌诊断与治疗的延误:一项多国分析。
Eur J Public Health. 2014 Oct;24(5):761-7. doi: 10.1093/eurpub/ckt131. Epub 2013 Sep 12.

通过坚持严格的诊断和治疗算法,优化认证乳腺中心的流程质量,研究结构和社会人口因素对治疗开始的影响。

Optimized process quality in certified breast centers through adherence to stringent diagnostic and therapeutic algorithms effects of structural as well as socio-demographic factors on start of therapy.

机构信息

Department of Obstetrics and Gynaecology, University Medical Centre Würzburg, Universitätsfrauenklinik Würzburg, Josef-Schneider-Straße 4, 97080, Würzburg, Germany.

出版信息

Arch Gynecol Obstet. 2023 Apr;307(4):1097-1104. doi: 10.1007/s00404-022-06666-2. Epub 2022 Aug 5.

DOI:10.1007/s00404-022-06666-2
PMID:35927591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10023602/
Abstract

PURPOSE

An increasing incidence of breast cancer can be observed worldwide. Since a delay of therapy can have a negative impact on prognosis, timely cancer care is an important quality indicator. By receiving treatment at a certified breast cancer center, the patient has the best chance of treatment in accordance with guidelines and the best prognosis. The identification of risk factors for a delay of therapy is of central importance and should be the basis for a continuous optimization of treatment at breast cancer centers.

METHODS

This retrospective study included women with breast cancer (primary diagnosis, relapse, or secondary malignancy) at the University Hospital Würzburg in 2019 and 2020. Data were retrieved from patients' records. Correlations and regression analyses were performed to detect potential risk factors for treatment delay.

RESULTS

Patients who received the histological confirmation of breast cancer at an external institution experienced a later therapy start than those patients who received the histological confirmation at the University Hospital Würzburg itself. (35.7 vs. 32.2 days). The interval between histological confirmation and the first consultation at the University Hospital Würzburg correlated statistically significant with age, distress and distance to the hospital.

CONCLUSION

Patients with an in-house diagnosis of breast cancer are treated more quickly than those whose diagnosis was confirmed in an external institution. We identified factors such as increased age, greater distance to the hospital as well as increased distress to prolong the time until start of oncological treatment. Intensified patient care should be offered to these subgroups.

摘要

目的

在全球范围内,乳腺癌的发病率不断上升。由于治疗的延误可能对预后产生负面影响,因此及时进行癌症治疗是一个重要的质量指标。通过在认证的乳腺癌中心接受治疗,患者有最好的机会按照指南进行治疗并获得最佳预后。确定治疗延误的风险因素至关重要,应成为乳腺癌中心不断优化治疗的基础。

方法

本回顾性研究纳入了 2019 年和 2020 年在维尔茨堡大学医院就诊的乳腺癌女性患者(初诊、复发或继发性恶性肿瘤)。数据来自患者记录。进行相关性和回归分析,以检测治疗延误的潜在风险因素。

结果

在外部机构获得乳腺癌组织学确诊的患者比在维尔茨堡大学医院获得组织学确诊的患者开始治疗的时间晚(35.7 天 vs. 32.2 天)。组织学确诊与在维尔茨堡大学医院首次就诊之间的间隔与年龄、痛苦和与医院的距离具有统计学显著相关性。

结论

在内部诊断为乳腺癌的患者比在外部机构确诊的患者接受治疗的速度更快。我们确定了一些因素,如年龄增加、与医院的距离增加以及痛苦增加,这些因素会延长开始肿瘤治疗的时间。应向这些亚组提供强化的患者护理。