Katz Almog, Gonen Meital, Shahar Yael, Roichman Asael, Lerrer Batia, Cohen Haim Yosef
The Mina & Everard Goodman Faculty of Life Sciences, The Sagol Center for Healthy Human Longevity, Bar-Ilan University, Ramat-Gan, Israel.
Front Neurosci. 2022 Jul 19;16:897005. doi: 10.3389/fnins.2022.897005. eCollection 2022.
The modern lifestyle requires less physical activity and skills during our daily routine, leading to multiple pathologies related to physical disabilities and energy accessibility. Thus, exploring the mechanisms underlying the metabolic regulation of exercise is crucial. Here, we characterized the effect of forced and voluntary endurance exercises on three key metabolic signaling pathways, sirtuins, AMPK, and mTOR, across several metabolic tissues in mice: brain, muscles, and liver. Both voluntary and forced exercises induced AMPK with higher intensity in the first. The comparison between those metabolic tissues revealed that the hypothalamus and the hippocampus, two brain parts, showed different metabolic signaling activities. Strikingly, despite the major differences in the physiology of muscles and hypothalamic tissues, the hypothalamus replicates the metabolic response of the muscle in response to physical exercise. Specifically, muscles and hypothalamic tissues showed an increase and a decrease in AMPK and mTOR signaling, respectively. Overall, this study reveals new insight into the relation between the hypothalamus and muscles, which enhances the coordination within the muscle-brain axis and potentially improves the systemic response to physical activity performance and delaying health inactivity disorders.
现代生活方式使我们在日常活动中所需的体力活动和技能减少，导致了多种与身体残疾和能量获取相关的疾病。因此，探索运动代谢调节的潜在机制至关重要。在此，我们研究了强迫性和自愿性耐力运动对小鼠多个代谢组织（脑、肌肉和肝脏）中三种关键代谢信号通路（sirtuins、AMPK和mTOR）的影响。自愿运动和强迫运动均首先以更高强度诱导AMPK。这些代谢组织之间的比较显示，下丘脑和海马体这两个脑区表现出不同的代谢信号活动。令人惊讶的是，尽管肌肉和下丘脑组织的生理学存在重大差异，但下丘脑在对体育锻炼的反应中复制了肌肉的代谢反应。具体而言，肌肉和下丘脑组织分别显示出AMPK信号增加和mTOR信号减少。总体而言，这项研究揭示了下丘脑与肌肉之间关系的新见解，增强了肌肉-脑轴内的协调性，并可能改善对体育活动表现的全身反应以及延缓健康不活动障碍。
