Farooqui Nahid, Bajaj Bindu
Department of Obstetrics and Gynaecology, VMMC and Safdarjung Hospital, Delhi, India.
J Obstet Gynaecol India. 2022 Aug;72(Suppl 1):299-305. doi: 10.1007/s13224-021-01583-x. Epub 2022 Feb 3.
To compare the pregnancy rates of two methods of intrauterine insemination (IUI), i.e. standard IUI (sIUI) and fallopian tube sperm perfusion (FSP).
This prospective randomised parallel study design included 160 infertile women < 38 years of age where IUI was indicated. We recorded a detailed history and conducted a careful clinical examination with the performance of baseline investigations. Each patient was randomly allocated into two groups: Group sIUI ( = 80) and Group FSP ( = 80). The patients underwent two cycles of IUI for achieving clinical pregnancy. The conception of pregnancy among both groups was noted and compared.
The mean age of the females, mean age of the male partners, and duration of marriage in Group sIUI and FSP were comparable ( > 0.05). Compared to the sIUI group, the FSP group had significantly higher patients who conceived (15.97% vs. 6.54%, = 0.016). In the cases with unexplained infertility, in cycle 2, in the FSP group, there were significantly more patients who conceived (21.05% vs. 0.00%, = 0.047).
We conclude that FSP over two treatment cycles offers an advantage over the standard IUI and could replace the sIUI in specific indications such as unexplained infertility for artificial insemination. It could be used as an alternative for couples with non-tubal infertility before moving on to IVF treatment.
比较两种宫内授精（IUI）方法，即标准IUI（sIUI）和输卵管精子灌注（FSP）的妊娠率。
本前瞻性随机平行研究设计纳入了160名年龄小于38岁且有IUI指征的不孕女性。我们记录了详细病史并进行了仔细的临床检查及基线调查。每位患者被随机分为两组：sIUI组（n = 80）和FSP组（n = 80）。患者接受两个周期的IUI以实现临床妊娠。记录并比较两组的妊娠情况。
sIUI组和FSP组女性的平均年龄、男性伴侣的平均年龄以及婚姻持续时间具有可比性（P>0.05）。与sIUI组相比，FSP组的受孕患者显著更多（15.97%对6.54%，P = 0.016）。在不明原因不孕的病例中，在第2周期，FSP组受孕的患者明显更多（21.05%对0.00%，P = 0.047）。
我们得出结论，在两个治疗周期中，FSP比标准IUI具有优势，并且在人工授精的特定指征如不明原因不孕中可以替代sIUI。在进行体外受精治疗之前，它可以作为非输卵管性不孕夫妇的一种替代方法。
