Biacchiardi Chiara Perono, Revelli Alberto, Gennarelli Gianluca, Rustichelli Sergio, Moffa Federica, Massobrio Marco
Reproductive Medicine Unit, Department of Gynecological and Obstetrical Sciences, University of Torino, S. Anna Hospital, Torino, Italy.
Fertil Steril. 2004 Feb;81(2):448-51. doi: 10.1016/j.fertnstert.2003.06.015.
To compare the results of fallopian tube sperm perfusion (FSP) versus standard intrauterine insemination (IUI) in patients with unexplained infertility undergoing controlled ovarian hyperstimulation (COH).
Randomized, prospective, cross-over study.
Reproductive medicine unit of a university hospital.
PATIENT(S): Fifty-six couples with unexplained infertility.
INTERVENTION(S): COH was induced by recombinant FSH and monitored by serial transvaginal ultrasound. On the day of hCG administration during the first treatment cycle, patients were randomized to either IUI or FSP. Thereafter, in case no pregnancy was achieved, patients went on being treated with FSP and IUI in alternate cycles. A maximum of four treatment cycles per couple was performed. FSP was performed using a pediatric Foley's catheter inseminating 4 mL of sperm-enriched suspension; a Kremer-Delafontaine catheter delivering 0.5 mL of sperm suspension was used for IUI.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rate per cycle.
RESULT(S): One hundred twenty-seven cycles (58 FSP, 69 IUI) were performed. The clinical pregnancy rate per cycle was 21.7% for IUI and 8.6% for FSP, respectively. No major adverse effects were recorded for either technique.
CONCLUSION(S): After COH, FSP is less effective than IUI in couples with unexplained infertility.
比较在接受控制性卵巢刺激（COH）的不明原因不孕症患者中，输卵管内精子灌注（FSP）与标准宫腔内人工授精（IUI）的效果。
随机、前瞻性、交叉研究。
一所大学医院的生殖医学科。
56对不明原因不孕症夫妇。
采用重组促卵泡素诱导COH，并通过经阴道超声连续监测。在第一个治疗周期注射人绒毛膜促性腺激素（hCG）当天，患者被随机分为接受IUI或FSP治疗。此后，如果未受孕，患者在交替周期中继续接受FSP和IUI治疗。每对夫妇最多进行4个治疗周期。FSP采用小儿Foley导管注入4毫升富含精子的悬液；IUI采用Kremer-Delafontaine导管注入0.5毫升精子悬液。
每个周期的临床妊娠率。
共进行了127个周期（58个FSP周期，69个IUI周期）。IUI每个周期的临床妊娠率为21.7%，FSP为8.6%。两种技术均未记录到重大不良反应。
在COH后，对于不明原因不孕症夫妇，FSP的效果不如IUI。
