Elazab Reham, Alkhiary Mostafa, Bedairi Mohamed, Wageh Alaa
Resident of Obstetrics and Gynecology, Mansoura General Hospital, Mansoura, Egypt.
Obstetrics and Gynecology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
J Obstet Gynaecol India. 2022 Aug;72(Suppl 1):83-88. doi: 10.1007/s13224-021-01556-0. Epub 2021 Sep 24.
Tumor necrosis factor, Lipid Profile, and β-hCG are markers that proved to be changed with preeclampsia. We aim to study their combined use as predictors of the severity of preeclampsia.
A case-control study was conducted in our University Hospitals on pregnant women complicated by mild or severe PE and healthy normal pregnant women as a control group. Samples of these markers were taken at a gestational age between 28 and 36 weeks.
A total number of 90 pregnant women were selected. The first group was mild PE (17 cases), the second group was severe PE (28 cases), and the third group was normal pregnant women (control group 45 cases). There is a statistically significant positive correlation between β-hCG, triglycerides, Cholesterol, LDL, VLDL, and Tumor necrosis factor. These markers correlate with the severity of PE. HDL demonstrates a statistically significant negative correlation with TNF-α and β-hCG.
There is a strong correlation between the increase of TNF, β-hCG, triglycerides, LDL, and cholesterol in cases of PE. These markers are associated with the severity of PE. These markers can be incorporated into a predictive model for PE.
肿瘤坏死因子、血脂谱和β-人绒毛膜促性腺激素是已被证明在子痫前期会发生变化的标志物。我们旨在研究它们联合使用作为子痫前期严重程度预测指标的情况。
在我们的大学医院对患有轻度或重度子痫前期的孕妇以及作为对照组的健康正常孕妇进行了一项病例对照研究。在孕28至36周之间采集这些标志物的样本。
共选取了90名孕妇。第一组为轻度子痫前期（17例），第二组为重度子痫前期（28例），第三组为正常孕妇（对照组45例）。β-人绒毛膜促性腺激素、甘油三酯、胆固醇、低密度脂蛋白、极低密度脂蛋白和肿瘤坏死因子之间存在统计学上显著的正相关。这些标志物与子痫前期的严重程度相关。高密度脂蛋白与肿瘤坏死因子-α和β-人绒毛膜促性腺激素呈统计学上显著的负相关。
子痫前期病例中肿瘤坏死因子、β-人绒毛膜促性腺激素、甘油三酯、低密度脂蛋白和胆固醇的升高之间存在强烈相关性。这些标志物与子痫前期的严重程度相关。这些标志物可纳入子痫前期的预测模型。
