Jain Shivi, Jain Madhu, Shukla R C
Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 Uttar Pradesh India.
Department of Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 Uttar Pradesh India.
J Obstet Gynaecol India. 2022 Aug;72(Suppl 1):274-280. doi: 10.1007/s13224-021-01557-z. Epub 2021 Oct 9.
To correlate the clinical, hormonal, biochemical and ultrasound parameters in adolescent patients with polycystic ovarian syndrome (PCOS) and to compare them with adult patients.
This was a prospective, correlational study. 50 adult (20-35 years) and 50 adolescent patients (15-19 years) who had features of PCOS (Rotterdam Criteria, 2003) were selected. The control group comprised of 50 women of same age in each group with normal parameters. Pelvic ultrasound was done in early follicular phase (3-5th day of menstrual cycle). Assessment of hormonal and biochemical parameters (LH/FSH ratio, free testosterone level, lipid profile and fasting glucose/insulin ratio) and grey-scale ultrasound was done.
No significant difference was observed in menstrual pattern in adults and adolescents with PCOS. The mean values of serum LH/FSH ratio and free testosterone were significantly higher in both adult and adolescent PCOS patients as compared to their controls ( < 0.001). The mean value of serum insulin was significantly higher ( < 0.001) with positive correlation (adult: = 0.655, < 0.01; adolescent: = 0.451, < 0.01) of serum insulin with free testosterone. Hyperandrogenemia without hyperinsulinemia was found in 56% adolescent and 60% adult PCOS patients. 82% adolescent and 88% adult PCOS patients showed multiple follicles (> 5) on ultrasound. The ovarian morphology had positive correlation with serum LH and free testosterone. The mean ovarian volume was significantly higher in adult (10.48 ± 4.38 vs. 4.17 ± 0.91) and adolescent (11.08 ± 5.82 vs. 4.23 ± 0.89) PCOS patients, when compared with controls, respectively.
No statistically significant difference was noted in PCOS between adults and adolescents.
关联多囊卵巢综合征（PCOS）青少年患者的临床、激素、生化及超声参数，并与成年患者进行比较。
这是一项前瞻性相关性研究。选取了50名成年（20 - 35岁）和50名青少年（15 - 19岁）具有PCOS特征（2003年鹿特丹标准）的患者。对照组由每组50名参数正常的同龄女性组成。在卵泡早期（月经周期第3 - 5天）进行盆腔超声检查。评估激素和生化参数（LH/FSH比值、游离睾酮水平、血脂谱和空腹血糖/胰岛素比值）以及灰阶超声。
PCOS成年和青少年患者的月经模式未观察到显著差异。与各自对照组相比，成年和青少年PCOS患者的血清LH/FSH比值和游离睾酮平均值均显著更高（<0.001）。血清胰岛素平均值显著更高（<0.001），且血清胰岛素与游离睾酮呈正相关（成年：=0.655，<0.01；青少年：=0.451，<0.01）。56%的青少年和60%的成年PCOS患者存在高雄激素血症但无高胰岛素血症。82%的青少年和88%的成年PCOS患者超声显示有多个卵泡（>5个）。卵巢形态与血清LH和游离睾酮呈正相关。与对照组相比，成年（10.48±4.38 vs. 4.17±0.91）和青少年（11.08±5.82 vs. 4.23±0.89）PCOS患者的平均卵巢体积均显著更高。
PCOS成年和青少年患者之间未发现统计学上的显著差异。
