Wang Xue, Ma Rui, Liu Xinyi, Zhang Yongbo
Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Front Neurol. 2022 Jul 19;13:948599. doi: 10.3389/fneur.2022.948599. eCollection 2022.
Cognitive impairment and neuropsychiatric disorders are very common in patients with temporal lobe epilepsy (TLE). These comorbidities complicate the treatment of epilepsy and seriously affect the quality of life. So far, there is still no effective intervention to prevent the development of epilepsy-associated comorbidities. Gut dysbiosis has been recognized to be involved in the pathology of epilepsy development. Modulating gut microbiota by probiotics has shown an antiseizure effect on humans and animals with epilepsy. Whether this treatment strategy has a positive effect on epilepsy-associated comorbidities remains unclear. Therefore, this study aimed to objectively assess the effect of probiotics on cognitive function and neuropsychiatric performance of patients with TLE. Participants enrolled in an epilepsy clinic were randomly assigned to the probiotic and placebo groups. These two groups were treated with probiotics or placebo for 12 weeks, and then the cognitive function and psychological performance of participants were assessed. We enrolled 76 participants in this study, and 70 subjects were finally included in the study (35 in the probiotics group and 35 in the placebo group). Our results showed significant seizure reduction in patients with TLE treated with probiotics. No significant differences were observed on cognitive function (including intelligence and memory) between groups. For neuropsychiatric performances, supplementation of probiotics significantly decreased the Hamilton Anxiety Rating and Depression Scale scores and increased the 89-item Quality of Life in Epilepsy Inventory score in patients with TLE. In conclusion, probiotics have a positive impact on seizures control, and improve anxiety, depression, and quality of life in patients with TLE.
认知障碍和神经精神疾病在颞叶癫痫（TLE）患者中非常常见。这些合并症使癫痫的治疗变得复杂，并严重影响生活质量。到目前为止，仍然没有有效的干预措施来预防癫痫相关合并症的发展。肠道菌群失调已被认为与癫痫发展的病理过程有关。通过益生菌调节肠道微生物群已显示出对癫痫患者和动物具有抗癫痫作用。这种治疗策略对癫痫相关合并症是否有积极影响仍不清楚。因此，本研究旨在客观评估益生菌对TLE患者认知功能和神经精神表现的影响。招募到癫痫门诊的参与者被随机分配到益生菌组和安慰剂组。这两组分别用益生菌或安慰剂治疗12周，然后评估参与者的认知功能和心理表现。本研究共招募了76名参与者，最终70名受试者被纳入研究（益生菌组35名，安慰剂组35名）。我们的结果显示，用益生菌治疗的TLE患者癫痫发作显著减少。两组在认知功能（包括智力和记忆）方面未观察到显著差异。对于神经精神表现，补充益生菌显著降低了TLE患者的汉密尔顿焦虑量表评分和抑郁量表评分，并提高了癫痫患者生活质量89项量表评分。总之，益生菌对癫痫控制有积极影响，并改善了TLE患者的焦虑、抑郁和生活质量。
