Parasitologie - Mycologie - Médecine tropicale, Hôpital Bretonneau, CHRU Tours, Tours, France.
Centre d'étude des pathologies respiratoires - Inserm U1100, faculté de Médecine, Université de Tours, Tours, France.
Front Cell Infect Microbiol. 2022 Jul 19;12:757200. doi: 10.3389/fcimb.2022.757200. eCollection 2022.
Aspergillosis remains difficult to diagnose in animals. Laboratory-based assays are far less developed than those for human medicine, and only few studies have been completed to validate their utility in routine veterinary diagnostics. To overcome the current limitations, veterinarians and researchers have to propose alternative methods including extrapolating from human diagnostic tools and using innovative technology. In the present overview, two specific examples were complementarily addressed in penguins and dolphins to illustrate how is challenging the diagnosis of aspergillosis in animals. Specific focus will be made on the novel application of simple testing in blood based on serological assays or protein electrophoresis and on the new information garnered from metabolomics/proteomics to discover potential new biomarkers. In conclusion, while the diagnostic approach of aspergillosis in veterinary medicine cannot be directly taken from options developed for human medicine, it can certainly serve as inspiration.
曲霉菌病在动物中仍然难以诊断。基于实验室的检测方法远不如人类医学中的检测方法发达，只有少数研究完成了验证其在常规兽医诊断中的实用性。为了克服当前的局限性，兽医和研究人员必须提出替代方法，包括从人类诊断工具推断和使用创新技术。在本综述中，通过互补的方式在企鹅和海豚中研究了两个具体的例子，以说明在动物中诊断曲霉菌病的挑战性。将特别关注基于血清学检测或蛋白质电泳的血液中简单检测的新应用，以及从代谢组学/蛋白质组学中获取的新信息，以发现潜在的新生物标志物。总之，虽然兽医曲霉菌病的诊断方法不能直接采用为人类医学开发的方法，但它肯定可以提供灵感。
