Debergh Hanne, Haesendonck Roel, Botteldoorn Nadine, Martel An, Pasmans Frank, Saegerman Claude, Packeu Ann
Scientific Department Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium.
Fundamental and Applied Research for Animal and Health (FARAH) Center, ULiège, 4000 Liège, Belgium.
One Health. 2024 Oct 2;19:100907. doi: 10.1016/j.onehlt.2024.100907. eCollection 2024 Dec.
Aspergillosis causes significant health risks to both birds and mammals. The outcome of these infections is often poor due to delayed diagnosis and treatment failure. We investigated 152 cases of aspergillosis from birds and mammals in Belgium. Most samples originated from the taxonomic orders Artiodactyla (40.1 %) and Columbiformes (19.7 %). Five isolates (3.3 %) showed phenotypical resistance against at least one medical azole. Three of these isolates were pan-azole resistant bearing the TR34/L98H mutation. The predominance of this resistance mutation supports an environmental route for exposure and resistance selection, highlighting the importance of the One Health concept.
曲霉病对鸟类和哺乳动物都构成重大健康风险。由于诊断延迟和治疗失败，这些感染的结果往往很差。我们调查了比利时152例鸟类和哺乳动物的曲霉病病例。大多数样本来自偶蹄目（40.1%）和鸽形目（19.7%）。五株分离株（3.3%）对至少一种医用唑类药物表现出表型耐药性。其中三株分离株携带TR34/L98H突变，对所有唑类药物均耐药。这种耐药突变的优势支持了环境暴露和耐药性选择途径，凸显了“同一健康”概念的重要性。
