Irani D R, Underwood R D, Johnson E H, Greenberg S D
Arch Intern Med. 1987 Jun;147(6):1133-6.
From 1978 to 1982, 620 pleural fluid cytology specimens were examined, of which 80 were positive in 64 patients. Of these 64, three (0.5%) specimens had false-positive results. Adenocarcinoma of the lung was the most frequent (25 of 61) primary site, followed by breast (12 of 61), ovary (six of 61), and pancreas (five of 61). Comparing cytology with pleural core needle biopsy specimens in 26 patients, the cytology results were positive in 96%, while the needle biopsy specimens alone were positive in only 69%. Following the diagnoses of malignant pleural effusions, the patients receiving combined chemotherapy and radiotherapy had a mean survival of 328 days, compared with only 79 days for those who received no therapy. In conclusion, cytologic examination of Papanicolaou-stained smears yielded a greater percentage of positive diagnoses than either cell block preparations or pleural needle biopsy specimens. Over the past 25 years, the mean survival after the diagnosis of malignant pleural effusions has shown no improvement.
1978年至1982年期间，共检查了620份胸水细胞学标本，其中80份在64例患者中呈阳性。在这64例中，有3份标本（0.5%）出现假阳性结果。肺癌是最常见的原发部位（61例中有25例），其次是乳腺癌（61例中有12例）、卵巢癌（61例中有6例）和胰腺癌（61例中有5例）。对26例患者的细胞学检查结果与胸膜芯针活检标本进行比较，细胞学检查结果阳性率为96%，而单独的针活检标本阳性率仅为69%。在诊断为恶性胸腔积液后，接受联合化疗和放疗的患者平均生存期为328天，而未接受治疗的患者平均生存期仅为79天。总之，巴氏染色涂片的细胞学检查比细胞块制备或胸膜针活检标本的阳性诊断率更高。在过去25年中，恶性胸腔积液诊断后的平均生存期没有改善。
