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介入肺科医生视角:恶性胸腔积液的治疗

Interventional pulmonologist perspective: treatment of malignant pleural effusion.

作者信息

Sweatt Andrew J, Sung Arthur

机构信息

Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA, USA,

出版信息

Curr Treat Options Oncol. 2014 Dec;15(4):625-43. doi: 10.1007/s11864-014-0312-6.

Abstract

The management of known malignant pleural effusions focuses around the initial thoracentesis and subsequent objective and subjective findings. A completely reexpanded lung after fluid removal and with symptomatic improvement predicts successful pleurodesis. Pleurodesis method depends on center expertise as well as patient preference. Medical thoracoscopy does not require the operating room setting and is performed on the spontaneously breathing patient with similar success rate to surgical thoracoscopy in the appropriately selected patients. However, it is not widely available. Talc insufflation is preferred for even distribution of sprayed particles to pleural surfaces. Most often, patients can be discharged home within 24 to 48 hours after continuous chest tube suction. Indwelling pleural catheter has become popular given the ease of insertion and patient centered home drainage. Coordinated care with good patient and family education and support is paramount to maximizing the beneficial potential of the catheter. Complications are minimal, and catheters are easily removed if patients can no longer benefit from drainage, or if pleurodesis has occurred. In the setting of trapped lung as a result of visceral pleura encasement from tumor, indwelling catheter can still be useful if the patient improves with thoracentesis. However, if no subjective improvement is seen after thoracentesis for trapped lung, then no procedure is recommended and other modes of palliation should be sought.

摘要

已知恶性胸腔积液的管理重点在于初始胸腔穿刺术以及后续的客观和主观发现。液体清除后肺完全复张且症状改善预示着胸膜固定术成功。胸膜固定术的方法取决于中心的专业水平以及患者的偏好。内科胸腔镜检查不需要手术室环境,在自主呼吸的患者身上进行,在适当选择的患者中其成功率与外科胸腔镜检查相似。然而,其应用并不广泛。滑石粉吹入法有利于将喷洒的颗粒均匀分布于胸膜表面。大多数情况下,持续胸腔闭式引流24至48小时后患者即可出院回家。由于留置胸膜导管易于插入且以患者为中心进行家庭引流,已变得很流行。良好的患者及家属教育与支持下的协调护理对于最大限度发挥导管的有益潜力至关重要。并发症极少,如果患者不再能从引流中获益或已发生胸膜固定术,导管很容易取出。在因肿瘤导致脏层胸膜包裹而出现肺陷闭的情况下,如果患者胸腔穿刺术后病情改善,留置导管仍可能有用。然而,如果胸腔穿刺术后肺陷闭未见主观改善,则不建议进行任何操作,应寻求其他姑息治疗方式。

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