Division of Surgical Oncology at Department of Surgery, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama.
Cancer Discov. 2022 Aug 5;12(8):1838-1840. doi: 10.1158/2159-8290.CD-22-0612.
In this issue of Cancer Discovery, Drewes and colleagues demonstrate a surprising role for the common gut pathogen Clostridioides difficile in driving colorectal cancer in preclinical models through the bacterial toxin-dependent reprogramming of the epithelial and immune compartments. See related article by Drewes et al., p. 1873 (3).
在本期《癌症发现》中，Drewes 及其同事通过依赖于细菌毒素的上皮和免疫区室重编程，在临床前模型中证明了常见肠道病原体艰难梭菌在推动结直肠癌方面的惊人作用。参见 Drewes 等人的相关文章，第 1873 页（3）。
