Fu Yacheng, Quan Changyun, Liu Lixia, Zhang Wei
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008.
Cofoe Medical Technology Co. Ltd., Changsha, 410000.
Zhongguo Yi Liao Qi Xie Za Zhi. 2022 Jul 30;46(4):422-427. doi: 10.3969/j.issn.1671-7104.2022.04.015.
The continuous glucose monitoring system (CGMS) has been clinically applied to monitor the dynamic change of the subcutaneous interstitial glucose concentration which is a function of the blood glucose level by glucose sensors. It can track blood glucose levels all day along, and thus provide comprehensive and reliable information about blood glucose dynamics. The clinical application of CGMS enables monitoring of blood glucose fluctuations and the discovery of hidden hyperglycemia and hypoglycemia that are difficult to be detected by traditional methods. As a CGMS needs to work subcutaneously for a long time, a series of factors such as biocompatibility, enzyme inactivation, oxygen deficiency, foreign body reaction, implant size, electrode flexibility, error correction, comfort, device toxicity, electrical safety, et al. should be considered beforehand. The study focused on the difficulties in the technology, and compared the products of Abbott, Medtronic and DexCom, then summarized their cutting-edge. Finally, this study expounded some key technologies in dynamic blood glucose monitoring and therefore can be utilized as a reference for the development of CGMS.
连续血糖监测系统（CGMS）已在临床上用于监测皮下组织间液葡萄糖浓度的动态变化，该浓度是通过葡萄糖传感器反映血糖水平的一个指标。它可以全天跟踪血糖水平，从而提供有关血糖动态变化的全面而可靠的信息。CGMS的临床应用能够监测血糖波动，并发现传统方法难以检测到的隐匿性高血糖和低血糖。由于CGMS需要长时间在皮下工作，因此事先应考虑一系列因素，如生物相容性、酶失活、缺氧、异物反应、植入尺寸、电极柔韧性、误差校正、舒适度、设备毒性、电气安全性等。本研究聚焦于该技术中的难点，比较了雅培、美敦力和德康的产品，总结了它们的前沿技术。最后，本研究阐述了动态血糖监测中的一些关键技术，可为CGMS的研发提供参考。
