Sachedina N, Pickup J C
Metabolic Unit, Guy's, King's and St Thomas's School of Medicine, Guy's Hospital, London, UK.
Diabet Med. 2003 Dec;20(12):1012-5. doi: 10.1046/j.1464-5491.2003.01037.x.
To assess the accuracy, reliability and measurement of glycaemic control associated with the Medtronic-MiniMed Continuous Glucose Monitoring System (CGMS) in comparison with blood glucose self-monitoring (BGSM) in Type 1 diabetic patients.
Type 1 diabetic patients (n = 18) underwent glucose monitoring by the CGMS for up to 3 days, when control was also assessed by BGSM performed eight times daily.
Ninety-five per cent of paired non calibration samples were in the clinically acceptable zones of the Clarke error grid, and 97% in a consensus grid. The median bias was 0.1 mmol/l and relative bias 15%. The failure rate of sensors was 28% of those initially inserted. The CGMS detected significantly more hypoglycaemia and post-prandial hyperglycaemia, but total duration of hyperglycaemia, blood glucose oscillations and day-to-day variability were similarly assessed by CGMS and BGSM.
The CGMS has acceptable clinical accuracy. Detection by the CGMS of more hypoglycaemia and post-prandial hyperglycaemia than BGSM promises a valuable tool for control assessment and optimization of treatment.
评估美敦力 - 敏悦持续葡萄糖监测系统（CGMS）与1型糖尿病患者的血糖自我监测（BGSM）相比，在血糖控制方面的准确性、可靠性及测量情况。
18例1型糖尿病患者使用CGMS进行长达3天的血糖监测，同时通过每日8次的BGSM评估血糖控制情况。
95%的未校准配对样本位于克拉克误差网格的临床可接受区域，97%位于共识网格。中位数偏差为0.1 mmol/L，相对偏差为15%。传感器的失败率为最初插入数量的28%。CGMS检测到的低血糖和餐后高血糖显著更多，但CGMS和BGSM对高血糖总时长、血糖波动及每日变异性的评估相似。
CGMS具有可接受的临床准确性。与BGSM相比，CGMS检测到更多的低血糖和餐后高血糖，这使其成为控制评估和优化治疗的宝贵工具。
