Kleinrok Z, Chmielewska B, Rajtar G, Sawiniec Z, Jarzabek G
Arch Immunol Ther Exp (Warsz). 1986;34(3):305-13.
Comparison of pharmacological properties of commercial, racemic trofosfamide (Ixoten) and its dextrorotatory and levorotatory derivatives was performed in experiments on mice. Acute and cumulative toxicity, behavioral screening tests and effects of subchronic treatment (growth of body mass, mortality, blood morphology, proteins level, enzymes activity, microscopic evaluation of liver slices) were taken into account. Summarized data revealed more pronounced toxicity of enantiomers, particularly D-form, as compared with racemate.
在小鼠实验中对市售消旋曲磷胺（Ixoten）及其右旋和左旋衍生物的药理学特性进行了比较。考虑了急性和累积毒性、行为筛选试验以及亚慢性治疗的效果（体重增长、死亡率、血液形态学、蛋白质水平、酶活性、肝脏切片的显微镜评估）。汇总数据显示，与消旋体相比，对映体尤其是D型对映体的毒性更为明显。
